Autophagy activation by interferon-γ via the p38 mitogen-activated protein kinase signalling pathway is involved in macrophage bactericidal activity

Summary Macrophages are involved in many essential immune functions. Their role in cell‐autonomous innate immunity is reinforced by interferon‐γ ( IFN ‐γ), which is mainly secreted by proliferating type 1 T helper cells and natural killer cells. Previously, we showed that IFN ‐γ activates autophagy via p38 mitogen‐activated protein kinase (p38 MAPK ), but the biological importance of this signalling pathway has not been clear. Here, we found...