Colonic MUC2 mucin regulates the expression and antimicrobial activity of β-defensin 2
Abstract
In this study we identified mechanisms at the colonic mucosa by which MUC2 mucin regulated the production of β-defensin in a proinflammatory milieu but functionally protected susceptible bacteria from its antimicrobial effects. The regulator role of MUC2 on production of β-defensin 2 in combination with the proinflammatory cytokine interleukin-1β (IL-1β) was confirmed using purified human colonic MUC2 mucin and colonic goblet cells short hairpin...
Paper Details
Title
Colonic MUC2 mucin regulates the expression and antimicrobial activity of β-defensin 2
Published Date
Nov 1, 2015
Journal
Volume
8
Issue
6
Pages
1360 - 1372
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Notes
History