The role of mitochondrial DNA damage in the citotoxicity of reactive oxygen species

Volume: 43, Issue: 1, Pages: 25 - 29
Published: Feb 1, 2011
Abstract
Mitochondria contain their own genome, a small circular molecule of around 16.5 kbases. The mitochondrial DNA (mtDNA) encodes for only 13 polypeptides, but its integrity is essential for mitochondrial function, as all 13 proteins are regulatory subunits of the oxidative phosphorylation complexes. Nonetheless, the mtDNA is physically associated with the inner mitochondrial membrane, where the majority of the cellular reactive oxygen species are...
Paper Details
Title
The role of mitochondrial DNA damage in the citotoxicity of reactive oxygen species
Published Date
Feb 1, 2011
Volume
43
Issue
1
Pages
25 - 29
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