Vitamin D insufficiency and schizophrenia risk: Evaluation of hyperprolinemia as a mediator of association
Abstract
25-Hydroxyvitamin D (25(OH)D) deficits have been associated with schizophrenia susceptibility and supplementation has been recommended for those at-risk. Although the mechanism by which a deficit confers risk is unknown, vitamin D is a potent transcriptional modulator and can regulate proline dehydrogenase (PRODH) expression. PRODH maps to chromosome 22q11, a region conferring the highest known genetic risk of schizophrenia, and encodes proline...
Paper Details
Title
Vitamin D insufficiency and schizophrenia risk: Evaluation of hyperprolinemia as a mediator of association
Published Date
Jun 1, 2014
Journal
Volume
156
Issue
1
Pages
15 - 22
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