Structural insights into the PIP2 recognition by syntenin-1 PDZ domain
Volume: 366, Issue: 2, Pages: 373 - 378
Published: Feb 1, 2008
Abstract
Lipid-mediated regulatory mechanism of the C-terminal ligand binding to PDZ domains is not fully understood, despite their roles in subcellular organization. Here, we provide structural insights into the phosphatidylinositol 4,5-bisphosphate (PIP(2)) recognition mode of a PDZ domain, as revealed from the crystal structure of the phosphate-bound PDZ domain. Two adjacent phosphate ions bind to the basic residues close to the amino terminus of the...
Paper Details
Title
Structural insights into the PIP2 recognition by syntenin-1 PDZ domain
Published Date
Feb 1, 2008
Volume
366
Issue
2
Pages
373 - 378
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