The deleterious mutation load is insensitive to recent population history
Abstract
Jonathan Pritchard, Guy Sella and colleagues report an analysis using population genetic models to show that recent human demography is likely to have had little impact on the average burden of deleterious mutations. They examine two large exome sequence datasets and find that individuals of west African and European ancestry carry similar burdens of damaging mutations. Human populations have undergone major changes in population size in the...
Paper Details
Title
The deleterious mutation load is insensitive to recent population history
Published Date
Feb 9, 2014
Journal
Volume
46
Issue
3
Pages
220 - 224
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Notes
History