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Study of the Contribution of the State of Water to the Gel Properties of a Photocrosslinked Polyacrylic Acid Hydrogel using Magnetic Resonance Imaging

Published on Nov 1, 2014in Journal of Pharmaceutical Sciences3.197
· DOI :10.1002/jps.24140
Yoshinori Onuki15
Estimated H-index: 15
(Hoshi University),
Naoki Hasegawa2
Estimated H-index: 2
(Hoshi University)
+ 2 AuthorsKozo Takayama48
Estimated H-index: 48
(Hoshi University)
Abstract
Photocrosslinked polyacrylic acid (PAA–HEMA) hydrogels are a promising candidate for use in dermatological patch adhesives. To gain further knowledge about the properties of this gel, we investigated the T 1 relaxation time and the diffusion coefficient ( D ) of water in the hydrogels using magnetic resonance (MR) imaging. Hydrogels with different formulations and process factors were prepared and tested. The observed data were analyzed by ANOVA, which clarified the mode of action of the formulation and process factors based on these MR parameters. Various gel properties (i.e., gel fraction, swelling capacity, gel strength, and water-retention ability) were also measured, followed by a Bayesian network (BN) analysis. The BN allowed us to summarize well the relationships between the formulation and process factors, MR parameters, and gel properties. T 1 was associated with the swelling and water-retention properties of the hydrogel, whereas D was associated with gel formation and gel strength. Furthermore, this study clarified that T 1 and D mostly represented the hydration and water-compartmentalization effects of the hydrogel, respectively. In conclusion, the state of water seems to play an important role in the properties of the PAA–HEMA hydrogel. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:3532–3541, 2014
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