6-Gingerol prevents cisplatin-induced acute renal failure in rats

Background : Nephrotoxicity is a major complication and a dose limiting factor for cisplatin therapy. Recent evidence suggests that enhanced oxidative stress caused by oxygen‐centered free radicals may contribute to the pathogenesis of cisplatin‐induced acute renal failure. 6‐Gingerol is claimed to be a potent antioxidant. The present study was performed to explore the renoprotective potential of 6‐gingerol on cisplatin‐induced oxidative stress...