Senescent cells: SASPected drivers of age-related pathologies
Abstract
The progression of physiological ageing is driven by intracellular aberrations including telomere attrition, genomic instability, epigenetic alterations and loss of proteostasis. These in turn damage cells and compromise their functionality. Cellular senescence, a stable irreversible cell-cycle arrest, is elicited in damaged cells and prevents their propagation in the organism. Under normal conditions, senescent cells recruit the immune system...
Paper Details
Title
Senescent cells: SASPected drivers of age-related pathologies
Published Date
Sep 13, 2014
Journal
Volume
15
Issue
6
Pages
627 - 642
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Notes
History