A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample

The dopamine (DA) transporter DAT1 is a major target bound by cocaine in brain. We examined the influence of functional genetic variants in DAT1 on cocaine addiction. Repeat polymorphisms, including a 30-bp variable-number tandem repeat (VNTR) in intron 8 (Int8 VNTR) with two common alleles, were genotyped in cocaine-dependent abusers ( n = 699) and in controls with no past history of drug abuse ( n = 866) from São Paulo, Brazil. Positive...