Corticotropin-releasing factor in the dorsal raphe nucleus regulates activity of lateral septal neurons

Corticotropin-releasing factor (CRF) has substantial effects on brain serotonergic activity, especially in limbic structures related to stress and anxiety. For example, relatively low doses of CRF administered into the dorsal raphe nucleus (DRN) decrease DRN unit activity and serotonin release in the lateral septum (LS), a limbic target of the DRN. In contrast, higher doses of CRF tend to be excitatory on both endpoints. The present experiment...