pH-responsive lipid core micelles for tumour targeting

A new acid-sensitive drug-delivery nanocarrier has been developed for tumour targeting. The self-assembling co-polymer stearoyl–PEG–poly-sulfadimethoxine methacrylate (stearoyl–PEG–polySDM) was prepared to obtain micelles with responsive behaviour in the physiopathologic pH range. Stearoyl–PEG–polySDM was synthesised using a multi-step procedure that includes pH-sensitive sulfadimethoxine methacrylate polymerisation by AGET-ATRP at the amino...