Independent recruitment of Igh alleles in V(D)J recombination

How the vast majority of B cells express only one of the two alleles at their immunoglobulin loci remains a biological puzzle. Here, in mice reconstituted with a single haematopoietic stem cell, we demonstrate that each of the two immunoglobulin heavy chain ( Igh ) alleles has a similar probability to be the first to undergo V H to DJ H rearrangement. We also observe this similar probability in clones from multipotent and common lymphoid...