Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence
Abstract
Telomeres are specialized nucleoprotein structures, which protect chromosome ends and have been implicated in the ageing process. Telomere shortening has been shown to contribute to a persistent DNA damage response (DDR) during replicative senescence, the irreversible loss of division potential of somatic cells. Similarly, persistent DDR foci can be found in stress-induced senescence, although their nature is not understood. Here we show, using...
Paper Details
Title
Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence
Published Date
Feb 28, 2012
Journal
Volume
3
Issue
1
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