Read‐Across Prediction of the Acute Toxicity of Organic Compounds toward the Water Flea Daphnia magna

According to the European REACH Directive, the acute daphnid toxicity needs to be assessed for industrial chemicals with market volumes ≥1 t/a. Employing a data set of 1365 organic compounds with experimental 48‐h LC 50 data for Daphnia magna , a read‐across approach has been developed that makes use of the atom‐centered fragment (ACF) method as quantitative measure for structural similarity. Both quantitative log LC 50 predictions and a...