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Anticancer activity of dinuclear gallium(III) carboxylate complexes

Published on Feb 1, 2010in European Journal of Medicinal Chemistry4.833
· DOI :10.1016/j.ejmech.2009.10.038
Milena R. Kaluđerović8
Estimated H-index: 8
(Leipzig University),
Santiago Gómez-Ruiz26
Estimated H-index: 26
(URJC: King Juan Carlos University)
+ 3 AuthorsGoran N. Kaluđerović27
Estimated H-index: 27
(University of Belgrade)
Abstract
Abstract The reaction of 3-methoxyphenylacetic acid, 4-methoxyphenylacetic acid, mesitylthioacetic acid, 2,5-dimethyl-3-furoic acid and 1,4-benzodioxane-6-carboxylic acid with trimethylgallium (1:1) yielded the dimeric complexes [Me 2 Ga(μ-O 2 CCH 2 C 6 H 4 -3-OMe)] 2 ( 1 ), [Me 2 Ga(μ-O 2 CCH 2 C 6 H 4 -4-OMe)] 2 ( 2 ), [Me 2 Ga(μ-O 2 CCH 2 SMes)] 2 ( 3 ) (Mes = 2,4,6-Me 3 C 6 H 2 ), [Me 2 Ga{μ-O 2 C(Fur)}] 2 ( 4 ) (Fur = 2,5-dimethylfuran) and [Me 2 Ga{μ-O 2 C(Bdo)}] 2 ( 5 ) (Bdo = 1,4-benzodioxane) respectively. The molecular structure of 5 was determined by X-ray diffraction studies. The cytotoxic activity of the gallium(III) complexes ( 1 – 5 ) was tested against human tumor cell lines 8505C anaplastic thyroid cancer, A253 head and neck tumor, A549 lung carcinoma, A2780 ovarian cancer, DLD-1 colon carcinoma and compared with that of cisplatin. Taking into account the standard deviation, there is no significant difference in the activity for any of the compounds in any cell line. However, complex 5 presents the best IC 50 value against A253 head and neck tumor (6.6 ± 0.2 μM), while complex 3 seems to be the most active against A2780 ovarian cancer (12.0 ± 0.4 μM) and marginally on DLD-1 colon carcinoma (12.4 ± 0.1 μM).
  • References (50)
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