Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy
Abstract
Endosomal protein sorting controls the localization of many physiologically important proteins and is linked to several neurodegenerative diseases. VPS35 is a component of the retromer complex, which mediates endosome-to-Golgi retrieval of membrane proteins such as the cation-independent mannose 6-phosphate receptor. Furthermore, retromer is also required for the endosomal recruitment of the actin nucleation promoting WASH complex. The VPS35...
Paper Details
Title
Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy
Published Date
May 13, 2014
Journal
Volume
5
Issue
1
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