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References40
Published on Jan 1, 1992in Nature 41.58
John E. Sulston47
Estimated H-index: 47
,
Z. Le Thi Huong Du1
Estimated H-index: 1
+ 1 AuthorsRobert B. Wilson21
Estimated H-index: 21
58 Citations
Published on Jan 1, 1979
John E. Hopcroft57
Estimated H-index: 57
,
Jeffrey D. Ullman95
Estimated H-index: 95
2,789 Citations
Published on Jan 25, 1987in Journal of Biological Chemistry 4.01
Yuen-Ling Chan19
Estimated H-index: 19
,
A. Lin1
Estimated H-index: 1
+ 3 AuthorsI. G. Wool1
Estimated H-index: 1
Abstract The covalent structure of rat ribosomal protein L19 was inferred from the sequence of nucleotides in a recombinant cDNA and confirmed from the sequence of amino acids in a portion of the protein. Ribosomal protein L19 contains 196 amino acids and has a molecular weight of 26,971. There are indications that a segment of 23 residues in rat L19 is related to sequences of the same length in Escherichia coli ribosomal proteins L30, L18, and S2.
119 Citations
Published on Sep 15, 1987in Journal of Biological Chemistry 4.01
A. Lin1
Estimated H-index: 1
,
Yuen-Ling Chan19
Estimated H-index: 19
+ 3 AuthorsI. G. Wool1
Estimated H-index: 1
Abstract The covalent structure of rat ribosomal protein L7 was determined in part from the sequence of nucleotides in a recombinant cDNA and in part from the sequence of amino acids in portions of the protein. The complementary analyses supplemented and confirmed each other. Ribosomal protein L7 contains 258 amino acids and has a molecular weight of 30,040. The protein has an unusual and striking structural feature near the NH2 terminus: five tandem repeats of a sequence of 12 residues. Rat L7 ...
30 Citations
Published on Jan 1, 1990in Methods in Enzymology 1.98
C. Burks1
Estimated H-index: 1
,
M.J. Cinkosky1
Estimated H-index: 1
+ 7 AuthorsK.E. Cumella1
Estimated H-index: 1
The GenBank1 database provides a collection of nucleotide sequences as well as relevant bibliographic and biological annotation. We present an updated view of the size and scope of the database, and we also describe recent developments in the strategies, protocols, and software for collecting, maintaining, and distributing the data.
41 Citations Source Cite
Published on Jun 5, 1988in Journal of Biological Chemistry 4.01
K W Shannon1
Estimated H-index: 1
,
J C Rabinowitz1
Estimated H-index: 1
Abstract C1-Tetrahydrofolate synthase is a trifunctional polypeptide found in eukaryotic organisms that catalyzes 10-formyltetrahydrofolate synthetase (EC 6.3.4.3), 5,10-methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9), and 5,10-methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5) activities. In Saccharomyces cerevisiae, C1-tetrahydrofolate synthase is found in both the cytoplasm and the mitochondria. The gene encoding yeast mitochondrial C1-tetrahydrofolate synthase was isolated using synth...
55 Citations
Published on Jan 1, 1990in Methods in Enzymology 1.98
Rodger Staden27
Estimated H-index: 27
Publisher Summary This chapter outlines some of the methods currently available to aid in the location of protein coding regions. The function of any particular coding region is to encode, with some level of accuracy and efficiency, using the genetic code and a given pool of tRNAs, a specific sequence of amino acids. The same region of DNA will have other functions. The basic assumption of the codon usage method is that all the genes within the sequence being analyzed have similar codon usage an...
69 Citations Source Cite
Published on Apr 19, 2001in Methods in Enzymology 1.98
Winona C. Barker33
Estimated H-index: 33
,
David G. George15
Estimated H-index: 15
,
Lois T. Hunt20
Estimated H-index: 20
The comprehensive, annotated and curated protein sequence databases – the PIR-International Protein Sequence Database and SWISS-PROT – support genome annotation, protein functional and structural analysis, proteomics, and phylogenetic studies. The databases are widely available, either free or by subscription, and are augmented by a variety of useful tools and related databases. Keywords: protein sequences; sequence databases; bioinformatics resources; protein superfamilies
69 Citations Source Cite
Published on Jan 5, 1990in Journal of Biological Chemistry 4.01
Chang jie Chen2
Estimated H-index: 2
(University of Illinois at Chicago),
Douglas P. Clark4
Estimated H-index: 4
(Howard Hughes Medical Institute)
+ 3 AuthorsIgor B. Roninson55
Estimated H-index: 55
(University of Illinois at Chicago)
Abstract The MDR1 gene, responsible for multidrug resistance in human cells, encodes a broad specificity efflux pump (P-glycoprotein). P-glycoprotein consists of two similar halves, each half including a hydrophobic transmembrane region and a nucleotide-binding domain. On the basis of sequence homology between the N-terminal and C-terminal halves of P-glycoprotein, we have previously suggested that this gene arose by duplication of a primordial gene. We have now determined the complete intron/ex...
232 Citations
Published on Jan 1, 1990in Methods in Enzymology 1.98
Steven Henikoff98
Estimated H-index: 98
,
James C. Wallace4
Estimated H-index: 4
,
Joseph P. Brown32
Estimated H-index: 32
Abstract In this chapter we describe strategies for the searching of translated nucleotide sequence databases. By applying standard searching techniques developed for protein databases, 6 we have found that previously unrecognized homologies can be detected. In addition, we have shown that extremely high sensitivity can be obtained using the scoring matrix strategy 11 for short regions of similarity. The latter approach is particularly effective for detecting homologs found at the ends of sequen...
133 Citations Source Cite
Cited By1354
Published on Feb 15, 1999in Blood 15.13
Cornel Popovici22
Estimated H-index: 22
,
Bin Zhang1
Estimated H-index: 1
+ 4 AuthorsMarie-Josèphe Pébusque25
Estimated H-index: 25
In patients with an atypical stem-cell myeloproliferative disorder with lymphoma (B or T cell), myeloid hyperplasia, and eosinophilia, the chromosome 8p11-12 region is the site of a recurrent breakpoint that can be associated with three different partners, 6q27, 9q32-34, and 13q12. Rearrangements are supposed to affect a pluripotent stem cell capable of myeloid and lymphoid differentiation and to involve the same 8p11-12 gene. The t(8;13) translocation has recently been shown to result in a fusi...
163 Citations
Published on Jan 1, 1996
Jean-Michel Claverie68
Estimated H-index: 68
(Centre national de la recherche scientifique)
Publisher Summary A growing number of laboratories throughout the world are actively engaged in the systematic sequencing of the genomes of a wide range of organisms. The complete genomic sequences of many viruses have also been determined, notably those of large DNA viruses. In the meantime, the positional cloning approach to the identification of human disease genes is contributing large human genomic sequences within the retinoblastoma susceptibility gene. In a complementary approach, express...
7 Citations Source Cite
Published on Jan 1, 1996
Seong-Gene Lee14
Estimated H-index: 14
,
Jueun Chung1
Estimated H-index: 1
(University of Ulsan)
+ 1 AuthorsKyuyoung Song27
Estimated H-index: 27
(University of Ulsan)
In the course of characterizing the nuclear antigen recognized by a monoclonal antibody 170A1, we isolated a novel human cDNA homologous to yeast SKI2, reported a partial cDNA sequence, and mapped the gene to chromosome 6p21 [7]. Subsequently the 5’ end of the gene was obtained by rapid amplification of cDNA ends and was sequenced. Here, we report the complete nucleotide sequence of the gene. A full length cDNA contains 3,898 nucleotides in length and predicts an open reading frame of 1,245 amin...
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Published on Jun 1, 2001in Virus Genes 1.54
Igor Oruetxebarria4
Estimated H-index: 4
,
Jari P. T. Valkonen51
Estimated H-index: 51
The immunocapture reverse transcriptase PCR method (IC-RT-PCR) was used to selectively amplify specific genome sequences of an isolate of Potato virus V (PVV, genus Potyvirus) from a potato plant infected by multiple viruses in the field in Finland. The sequences of the 5′- and 3′-non-translated regions (NTR) and the P1- and coat protein (CP)-encoding sequences were determined because they are the most variable genomic regions in potyviruses. The sequences of the new Finnish PVV isolate obtained...
10 Citations Source Cite
Published on Jan 1, 1998
Staffan Bergh4
Estimated H-index: 4
,
Stewart T. Cole92
Estimated H-index: 92
In recent years there has been a considerable upturn in interest in the genetics and microbiology of the mycobacteria (Young and Cole, 1993), and the reasons for this are two-fold. Firstly, after several decades of relative tranquility, mycobacterial diseases are assuming greater importance in terms of public health problems in the industrialized world and secondly, powerful new tools for working with mycobacteria have been developed that allow previously intractable biological and medical probl...
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Published on Jan 1, 1998
Luciano Milanesi26
Estimated H-index: 26
,
Igor B. Rogozin57
Estimated H-index: 57
An important problem in current molecular biology studies is gene identification. Due to recent progress in large-scale sequencing projects, gene identification programs have become widely used. The use of these programs can significantly simplify the analysis of newly sequenced DNA especially when applied in combination with experimental methods. The gene identification procedure is very complex owing to the structure of eukaryotic genes. The analysis of human genes cannot be considered merely ...
18 Citations Source Cite
Published on Jan 1, 2002
William Kent1
Estimated H-index: 1
248 Citations
Published on Jan 1, 2009
William H. Majoros25
Estimated H-index: 25
(Duke University),
Ian F Korf1
Estimated H-index: 1
,
Uwe Ohler41
Estimated H-index: 41
(Duke University)
Most computational gene-finding methods in current use are derived from the fields of natural language processing and speech recognition. These latter fields are concerned with parsing spoken or written language into functional components such as nouns, verbs, and phrases of various types. The parsing task is governed by a set of syntax rules that dictate which linguistic elements may immediately follow each other in well-formed sentences – for example, $$subject \rightarrow verb,\, verb \righta...
3 Citations Source Cite
Published on Aug 1, 2004in BioTechniques 2.10
Kar-wai Ng2
Estimated H-index: 2
(University of Texas Southwestern Medical Center),
Jonathan N. Lawson4
Estimated H-index: 4
(University of Texas Southwestern Medical Center),
Harold R. Garner39
Estimated H-index: 39
(University of Texas Southwestern Medical Center)
PathoGene™ is a web-based resource that streamlines the process of predicting genes in microorganisms and designs PCR primers for amplification to facilitate sequence analysis and experimentation. PathoGene currently supports primer design for every complete microbial, viral, and fungal genome as cataloged in GenBank® by the National Center for Biotechnology Information (NCBI; http://www.ncbi.nlm.nih.gov/). The resulting primers can then be subjected to a stand-alone Basic Local Alignment Search...
4 Citations Source Cite
Published on Jan 1, 1994
K. Gardiner (Roosevelt Institute), Hongxia Xu5
Estimated H-index: 5
(Yale University)
+ 6 AuthorsSherman M. Weissman74
Estimated H-index: 74
(Yale University)
Chromosome 21 is the smallest and one of the best mapped of the human chromosomes. It, therefore, represents a good model system for transcriptional mapping efforts. To construct a comprehensive transcriptional map, the technique of cDNA hybrid selection is being applied to a minimal contig of YAC clones spanning the long arm. Presented here are preliminary results for four YACs representing ≈2 Mb of non-overlapping DNA. While the cDNA hybrid selection approach is rapid and robust, several diffi...
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