Comparison of plasma active glucagon-like peptide-1 (GLP-1) levels assayed with or without plasma extraction in non-diabetic men

Recently, interference from cross-reacting peptides in plasma has been recognized as being responsible for inter-subject differences in active glucagon-like peptide-1 (GLP-1) values. An ethanol or solid-phase extraction step could reduce such interference. A working group of the Japan Diabetes Society now recommends the inclusion of an extraction step when measuring active GLP-1 values. We measured the active GLP-1 levels of 200 specimens...