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Audiovisual emotional processing and neurocognitive functioning in patients with depression

Published on Jan 30, 2015in Frontiers in Integrative Neuroscience
· DOI :10.3389/fnint.2015.00003
Sophie Doose-Grünefeld1
Estimated H-index: 1
(HHU: University of Düsseldorf),
Simon B. Eickhoff83
Estimated H-index: 83
(HHU: University of Düsseldorf),
Veronika I. Müller15
Estimated H-index: 15
(HHU: University of Düsseldorf)
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Abstract
Alterations in the processing of emotional stimuli (e.g. facial expressions, prosody, music) have repeatedly been reported in patients with major depression. Such impairments may result from the likewise prevalent executive deficits in these patients. However, studies investigating this relationship are rare. Moreover, most studies to date have only assessed impairments in unimodal emotional processing, whereas in real life, emotions are primarily conveyed through more than just one sensory channel. The current study therefore aimed at investigating multi-modal emotional processing in patients with depression and to assess the relationship between emotional and neurocognitive impairments. 41 patients suffering from major depression and 41 never-depressed healthy controls participated in an audiovisual (faces-sounds) emotional integration paradigm as well as a neurocognitive test battery. Our results showed that depressed patients were specifically impaired in the processing of positive auditory stimuli as they rated faces significantly more fearful when presented with happy than with neutral sounds. Such an effect was absent in controls. Findings in emotional processing in patients did not correlate with BDI-scores. Furthermore, neurocognitive findings revealed significant group differences for two of the tests. The effects found in audiovisual emotional processing, however, did not correlate with performance in the neurocognitive tests. In summary, our results underline the diversity of impairments going along with depression and indicate that deficits found for unimodal emotional processing cannot trivially be generalized to deficits in a multi-modal setting. The mechanisms of impairments therefore might be far more complex than previously thought. Our findings furthermore contradict the assumption that emotional processing deficits in major depression are associated with impaired attention or inhibitory functioning.
  • References (67)
  • Citations (6)
Cite
References67
Newest
Published on Jun 1, 2014in Social Cognitive and Affective Neuroscience3.66
Veronika I. Müller15
Estimated H-index: 15
(HHU: University of Düsseldorf),
Edna C. Cieslik16
Estimated H-index: 16
(HHU: University of Düsseldorf)
+ 1 AuthorsSimon B. Eickhoff83
Estimated H-index: 83
(HHU: University of Düsseldorf)
Major depression goes along with affective and social-cognitive deficits. Most research on affective deficits in depression has, however, only focused on unimodal emotion processing, whereas in daily life, emotional perception is often highly dependent on the evaluation of multimodal inputs. We thus investigated emotional audiovisual integration in patients with depression and healthy subjects. Subjects rated the expression of happy, neutral and fearful faces while concurrently being exposed to ...
Published on Jan 1, 2014in Journal of Affective Disorders4.08
Madhukar H. Trivedi89
Estimated H-index: 89
(UTSW: University of Texas Southwestern Medical Center),
Tracy L. Greer17
Estimated H-index: 17
(UTSW: University of Texas Southwestern Medical Center)
Abstract Objective The primary objective of this review is to examine the literature assessing abnormalities in neural circuitry and cognition early in the course of major depressive disorder (MDD) and the impact of these features on treatment selection and long-term outcomes. Data Sources English language and peer-reviewed publications were obtained by PubMed / Medline ( www.pubmed.org ) searches using combinations of major depressive disorder, major depression, or unipolar depression and “firs...
Published on Jan 1, 2014in Frontiers in Psychiatry3.16
Morten Kaletsch3
Estimated H-index: 3
(University of Giessen),
Sebastian Pilgramm12
Estimated H-index: 12
(University of Giessen)
+ 9 AuthorsKaren Zentgraf16
Estimated H-index: 16
(WWU: University of Münster)
Much recent research has shown an association between mood disorders and an altered emotion perception. However, these studies were conducted mainly with stimuli such as faces. This is the first study to examine possible differences in how people with major depressive disorder (MDD) and healthy controls perceive emotions expressed via body movements. Thirty patients with MDD and thirty healthy controls observed the video scenes of human interactions conveyed by point-light displays (PLDs). They ...
Published on Jan 1, 2014in Emotion3.13
Jonas Everaert10
Estimated H-index: 10
(UGent: Ghent University),
Wouter Duyck30
Estimated H-index: 30
(UGent: Ghent University),
Ernst H. W. Koster43
Estimated H-index: 43
(UGent: Ghent University)
Emotional biases in attention, interpretation, and memory are viewed as important cognitive processes underlying symptoms of depression. To date, there is a limited understanding of the interplay among these processing biases. This study tested the dependence of memory on depression-related biases in attention and interpretation. Subclinically depressed and nondepressed participants completed a computerized version of the scrambled sentences test (measuring interpretation bias) while their eye m...
Published on Nov 5, 2013in PLOS Medicine
Alize J. Ferrari46
Estimated H-index: 46
(Centre for Mental Health),
Fiona J Charlson40
Estimated H-index: 40
(Centre for Mental Health)
+ 5 AuthorsHarvey Whiteford60
Estimated H-index: 60
(Centre for Mental Health)
Background: Depressive disorders were a leading cause of burden in the Global Burden of Disease (GBD) 1990 and 2000 studies. Here, we analyze the burden of depressive disorders in GBD 2010 and present severity proportions, burden by country, region, age, sex, and year, as well as burden of depressive disorders as a risk factor for suicide and ischemic heart disease. Methods and Findings: Burden was calculated for major depressive disorder (MDD) and dysthymia. A systematic review of epidemiologic...
Published on Aug 1, 2013in Psychiatry Research-neuroimaging2.21
Felice Loi1
Estimated H-index: 1
(Centre for Mental Health),
Jatin G. Vaidya19
Estimated H-index: 19
(Roy J. and Lucille A. Carver College of Medicine),
Sergio Paradiso2
Estimated H-index: 2
(California Institute of Technology)
Major depression may be associated with abnormal perception of emotions and impairment in social adaptation. Emotion recognition from body language and its possible implications to social adjustment have not been examined in patients with depression. Three groups of participants (51 with depression; 68 with history of depression in remission; and 69 never depressed healthy volunteers) were compared on static and dynamic tasks of emotion recognition from body language. Psychosocial adjustment was...
Published on Mar 1, 2013in Psychophysiology3.38
Max Owens8
Estimated H-index: 8
(Birkbeck, University of London),
Ernst H. W. Koster43
Estimated H-index: 43
(UGent: Ghent University),
Nazanin Derakshan30
Estimated H-index: 30
(Birkbeck, University of London)
Impaired filtering of irrelevant information from working memory is thought to underlie reduced working memory capacity for relevant information in dysphoria. The current study investigated whether training-related gains in working memory performance on the adaptive dual n-back task could result in improved inhibitory function. Efficacy of training was monitored in a change detection paradigm allowing measurement of a sustained event-related potential asymmetry sensitive to working memory capaci...
Published on Feb 1, 2013
Vanessa C. Evans3
Estimated H-index: 3
(UBC: University of British Columbia),
Sarah Sl Chan1
Estimated H-index: 1
(UBC: University of British Columbia)
+ 3 AuthorsRaymond W. Lam57
Estimated H-index: 57
(UBC: University of British Columbia)
Occupational impairment accounts for much of the burden and economic costs associated with major depressive disorder (MDD). Many studies have documented neurocognitive deficits in MDD, and depression-associated cognitive dysfunction would be expected to have significant effects on occupational functioning. We systematically reviewed the literature for studies on neurocognition and occupational functioning in MDD. Electronic databases (e.g., MEDLINE, PsychInfo and Cochrane Clinical Trials) were s...
Published on Jan 1, 2013in Frontiers in Psychology2.13
Sarah Schlipf4
Estimated H-index: 4
(University of Tübingen),
Anil Batra27
Estimated H-index: 27
(University of Tübingen)
+ 4 AuthorsThomas Ethofer24
Estimated H-index: 24
(University of Tübingen)
It was the aim of this study to investigate the impact of major depressive disorder (MDD) on judgment of emotions expressed at the verbal (semantic content) and non-verbal (prosody) level and to assess whether evaluation of verbal content correlate with self-ratings of depression-related symptoms as assessed by Beck Depression Inventory (BDI). We presented positive, neutral, and negative words spoken in happy, neutral, and angry prosody to 23 MDD patients and 22 healthy controls (HC) matched for...
Published on Dec 1, 2012in Journal of Affective Disorders4.08
Bernhard T. Baune59
Estimated H-index: 59
(University of Adelaide),
Maria E. Czira19
Estimated H-index: 19
(University of Adelaide)
+ 2 AuthorsGrant Sinnamon7
Estimated H-index: 7
(University of Adelaide)
Abstract Background There is evidence for neuropsychological dysfunction in depression among adult and elderly participants but little research has been conducted on the neuropsychological functioning of youth with depression. The aim of the present study was to investigate the neuropsychological functioning of outpatient young participants with depression. Methods Computerised neuropsychological tests requiring executive functioning, working memory, attention, verbal memory and learning, planni...
Cited By6
Newest
Published on Apr 1, 2019in Psychiatry Research-neuroimaging2.21
M. Weightman6
Estimated H-index: 6
(University of Adelaide),
Matthew J. Knight4
Estimated H-index: 4
(University of Adelaide),
Bernhard T. Baune59
Estimated H-index: 59
(University of Adelaide)
Abstract Social cognition is the ability to identify, perceive and interpret socially relevant information from the external world. It is an important adaptive trait, but is frequently affected in major depressive disorder by a mood-congruent interpretive bias. The present review examined the existing body of literature to determine (i) the impact social cognitive deficits in depression have on psychosocial functioning; and (ii) the utility of psychotropic, psychological and procedural intervent...
Published on Aug 15, 2018in Frontiers in Psychology2.13
Christina Kauschke9
Estimated H-index: 9
(University of Marburg),
Nadine Mueller (University of Marburg)+ 1 AuthorsArne Nagels2
Estimated H-index: 2
(University of Mainz)
In everyday communication metaphoric expressions are frequently used to refer to abstract concepts, such as feelings or mental states. Patients with depression are said to prefer literal over figurative language, i.e. they may show a concreteness bias. Given that both emotional functioning and the processing of figurative language may be altered in this clinical population, our study aims at investigating whether and how these dysfunctions are reflected in the understanding and production of met...
Published on Feb 1, 2017in Journal of Athletic Training2.25
Jordan E. Cottle1
Estimated H-index: 1
,
Eric E. Hall21
Estimated H-index: 21
+ 2 AuthorsCaroline J. Ketcham7
Estimated H-index: 7
Context: Neurocognitive test scores are often considered an important aspect of concussion management. To best use these data, clinicians must understand potential factors that may influence baseline performance on these tests. Objective: To determine preexisting factors that may influence performance on the Immediate Post-Concussion Assessment and Cognitive Test (ImPACT). Design: Cross-sectional study. Setting: Research laboratory. Patients or Other Participants: A total of 486 National Collegi...
Published on Jan 1, 2017in JAMA Psychiatry15.92
Veronika I. Müller15
Estimated H-index: 15
(HHU: University of Düsseldorf),
Edna C. Cieslik16
Estimated H-index: 16
(HHU: University of Düsseldorf)
+ 3 AuthorsSimon B. Eickhoff83
Estimated H-index: 83
(HHU: University of Düsseldorf)
Importance During the past 20 years, numerous neuroimaging experiments have investigated aberrant brain activation during cognitive and emotional processing in patients with unipolar depression (UD). The results of those investigations, however, vary considerably; moreover, previous meta-analyses also yielded inconsistent findings. Objective To readdress aberrant brain activation in UD as evidenced by neuroimaging experiments on cognitive and/or emotional processing. Data Sources Neuroimaging ex...
Published on Oct 1, 2016in Neuroscience Letters2.17
April Hargreaves11
Estimated H-index: 11
(National College of Ireland),
O. Mothersill3
Estimated H-index: 3
(National University of Ireland, Galway)
+ 3 AuthorsGary Donohoe42
Estimated H-index: 42
(National University of Ireland, Galway)
Abstract Background Deficits in facial emotion recognition have been associated with functional impairments in patients with Schizophrenia (SZ). Whilst a strong ecological argument has been made for the use of both dynamic facial expressions and varied emotion intensities in research, SZ emotion recognition studies to date have primarily used static stimuli of a singular, 100%, intensity of emotion. To address this issue, the present study aimed to investigate accuracy of emotion recognition amo...
Published on Aug 1, 2016in Human Brain Mapping4.55
Timm B. Poeppl17
Estimated H-index: 17
(University of Regensburg),
Veronika I. Müller15
Estimated H-index: 15
(HHU: University of Düsseldorf)
+ 10 AuthorsValentin Riedl24
Estimated H-index: 24
(TUM: Technische Universität München)
Major depressive disorder (MDD) involves impairment in cognitive and interpersonal functioning. The right temporoparietal junction (RTPJ) is a key brain region subserving cognitive-attentional and social processes. Yet, findings on the involvement of the RTPJ in the pathophysiology of MDD have so far been controversial. Recent connectivity-based parcellation data revealed a topofunctional dualism within the RTPJ, linking its anterior and posterior part (aRTPJ/pRTPJ) to antagonistic brain network...
Published on Jul 7, 2016in Cerebral Cortex5.44
Alessandra D. Nostro2
Estimated H-index: 2
(HHU: University of Düsseldorf),
Veronika I. Müller15
Estimated H-index: 15
(HHU: University of Düsseldorf)
+ 1 AuthorsSimon B. Eickhoff83
Estimated H-index: 83
(HHU: University of Düsseldorf)
Previous studies have shown that males and females differ in personality and gender differences have also been reported in brain structure. However, effects of gender on this "personality-brain" relationship are yet unknown. We therefore investigated if the neural correlates of personality differ between males and females. Whole brain voxel-based morphometry was used to investigate the influence of gender on associations between NEO FFI personality traits and gray matter volume (GMV) in a matche...
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