Fms-Like Tyrosine Kinase 3 Protects Cardiomyocytes Against Oxidative Stress-Induced Apoptosis

BackgroundNew insights into the biology of the ischemic myocardium revealed the activation of endogenous cytokines that aim at mitigating acute ischemic cell damage and initiating cardiac repair. Fms-like tyrosine kinase 3 (Flt3) ligand (FL) is an early-acting hematopoietic cytokine that is involved in the regulation of proliferation, differentiation and survival of hematopoietic cells. FL is expressed in the human heart and mRNA levels of FL...