A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production
Abstract
Intracellular nucleotide binding and oligomerization domain (NOD) receptors recognize antigens including bacterial peptidoglycans and initiate immune responses by triggering the production of pro-inflammatory cytokines through activating NF-κB and MAP kinases. Receptor interacting protein kinase 2 (RIPK2) is critical for NOD-mediated NF-κB activation and cytokine production. Here we develop and characterize a selective RIPK2 kinase inhibitor,...
Paper Details
Title
A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production
Published Date
Mar 17, 2015
Journal
Volume
6
Issue
1
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