Propofol, an anesthetic possessing neuroprotective action against oxidative stress, promotes the process of cell death induced by H2O2 in rat thymocytes

Published on Jul 1, 2006in European Journal of Pharmacology3.17
· DOI :10.1016/j.ejphar.2006.04.037
Ken-ichi Chikutei2
Estimated H-index: 2
(Tokushima Bunri University),
Tomohiro M. Oyama11
Estimated H-index: 11
(Tokushima Bunri University)
+ 7 AuthorsYasuooyama30
Estimated H-index: 30
(University of Tokushima)
Abstract Propofol (2,6-diisopropylphenol) is a general anesthetic possessing a neuroprotective action against oxidative stress produced by H 2 O 2 . H 2 O 2 induces an exposure of phosphatidylserine on outer surface of cell membranes, resulting in change in membrane phospholipid arrangement, in rat thymocytes. Since propofol is highly lipophilic, the agent is presumed to interact with membrane lipids and hence to modify the cell vulnerability to H 2 O 2 . Therefore, to test the possibility, we have examined the effect of propofol on rat thymocytes simultaneously incubated with H 2 O 2 . Although propofol (up to 30 μM) alone did not significantly affect the cell viability, the agent at 10 μM started to increase the population of dead cells in the presence of 3 mM H 2 O 2 and the significant increase was observed at 30 μM. Propofol at clinically relevant concentrations (10–30 μM) facilitated the process of cell death induced by H 2 O 2 in rat thymocytes. However, propofol protected rat brain neurons against the oxidative stress induced by H 2 O 2 under same experimental condition. Therefore, the action of propofol may be dependent on the type of cells.
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