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Propofol, an anesthetic possessing neuroprotective action against oxidative stress, promotes the process of cell death induced by H2O2 in rat thymocytes

Published on Jul 1, 2006in European Journal of Pharmacology3.17
· DOI :10.1016/j.ejphar.2006.04.037
Ken-ichi Chikutei2
Estimated H-index: 2
(Tokushima Bunri University),
Tomohiro M. Oyama11
Estimated H-index: 11
(Tokushima Bunri University)
+ 7 AuthorsYasuooyama30
Estimated H-index: 30
(University of Tokushima)
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Abstract
Abstract Propofol (2,6-diisopropylphenol) is a general anesthetic possessing a neuroprotective action against oxidative stress produced by H 2 O 2 . H 2 O 2 induces an exposure of phosphatidylserine on outer surface of cell membranes, resulting in change in membrane phospholipid arrangement, in rat thymocytes. Since propofol is highly lipophilic, the agent is presumed to interact with membrane lipids and hence to modify the cell vulnerability to H 2 O 2 . Therefore, to test the possibility, we have examined the effect of propofol on rat thymocytes simultaneously incubated with H 2 O 2 . Although propofol (up to 30 μM) alone did not significantly affect the cell viability, the agent at 10 μM started to increase the population of dead cells in the presence of 3 mM H 2 O 2 and the significant increase was observed at 30 μM. Propofol at clinically relevant concentrations (10–30 μM) facilitated the process of cell death induced by H 2 O 2 in rat thymocytes. However, propofol protected rat brain neurons against the oxidative stress induced by H 2 O 2 under same experimental condition. Therefore, the action of propofol may be dependent on the type of cells.
  • References (35)
  • Citations (12)
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References35
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#1Yumiko Nishimura (University of Tokushima)H-Index: 14
#2Aimi Kanada (University of Tokushima)H-Index: 6
Last.Yasuooyama (University of Tokushima)H-Index: 30
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#1Jun-ya Yamaguchi (University of Tokushima)H-Index: 7
#2Yumiko Nishimura (University of Tokushima)H-Index: 14
Last.Yasuooyama (University of Tokushima)H-Index: 30
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#1Irina V. Balyasnikova (UIC: University of Illinois at Chicago)H-Index: 24
#2David J. Visintine (UIC: University of Illinois at Chicago)H-Index: 7
Last.Sergei M. Danilov (UIC: University of Illinois at Chicago)H-Index: 29
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#1Tomoko Tatsuishi (University of Tokushima)H-Index: 9
#2Yasuooyama (University of Tokushima)H-Index: 30
Last.Seigo Hirama (YCU: Yokohama City University)H-Index: 4
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#1İlhami Gülçin (Atatürk University)H-Index: 73
#2Haci Ahmet Alici (Atatürk University)H-Index: 12
Last.Mehmet Cesur (Atatürk University)H-Index: 12
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#1Yasutaka Nishizaki (University of Tokushima)H-Index: 6
#2Hiromi Nakao (University of Tokushima)H-Index: 10
Last.Yasuooyama (University of Tokushima)H-Index: 30
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Cited By12
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#1Xiaohui Chen (Fujian Medical University)H-Index: 4
#2Xue Zhou (SYSU: Sun Yat-sen University)H-Index: 5
Last.Xia Feng (SYSU: Sun Yat-sen University)H-Index: 5
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#1Mitsuuru Hata (Kanagawa Dental College)H-Index: 1
#2Kyo Kobayashi (Kanagawa Dental College)H-Index: 6
Last.Shun-suke Takahashi (Kanagawa Dental College)H-Index: 10
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