Original paper
Membrane attack by complement: the assembly and biology of terminal complement complexes
Abstract
Complement system activation plays an important role in both innate and acquired immunity. Activation of the complement and the subsequent formation of C5b-9 channels (the membrane attack complex) on the cell membranes lead to cell death. However, when the number of channels assembled on the surface of nucleated cells is limited, sublytic C5b-9 can induce cell cycle progression by activating signal transduction pathways and transcription factors...
Paper Details
Title
Membrane attack by complement: the assembly and biology of terminal complement complexes
Published Date
Aug 18, 2011
Journal
Volume
51
Issue
1
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Notes
History