Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency
Abstract
To understand the genetic predisposition to selective immunoglobulin A deficiency (IgAD), we performed a genome-wide association study in 430 affected individuals (cases) from Sweden and Iceland and 1,090 ethnically matched controls, and we performed replication studies in two independent European cohorts. In addition to the known association of HLA with IgAD, we identified association with a nonsynonymous variant in IFIH1 (rs1990760G>A, P = 7.3...
Paper Details
Title
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency
Published Date
Aug 8, 2010
Journal
Volume
42
Issue
9
Pages
777 - 780
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