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Rationale and Design of INTERSTROKE: A Global Case-Control Study of Risk Factors for Stroke

Published on Jan 1, 2010in Neuroepidemiology2.689
· DOI :10.1159/000306058
Martin O'Donnell54
Estimated H-index: 54
(McMaster University),
Denis Xavier49
Estimated H-index: 49
(St. John's University)
+ 24 AuthorsSalim Yusuf Mb Bs DPhil Frcpc214
Estimated H-index: 214
(McMaster University)
Abstract
Stroke is a major global health problem. It is the third leading cause of death and the leading cause of adult disability. INTERHEART, a global case-control study of acute myocardial infarction in 52
  • References (77)
  • Citations (45)
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References77
Newest
#1Andreas Gschwendtner (LMU: Ludwig Maximilian University of Munich)H-Index: 17
#2Steve Bevan (St George's, University of London)H-Index: 39
Last. Martin Dichgans (LMU: Ludwig Maximilian University of Munich)H-Index: 77
view all 20 authors...
Objective Recent studies have identified a major locus for risk of coronary artery disease (CAD) and myocardial infarction (MI) on chromosome 9p21.3. Stroke, in particular ischemic stroke (IS) due to atherosclerotic disease, shares common mechanisms with MI. We investigated whether the 9p21 region contributes to IS risk.
183 CitationsSource
#1Valery L. Feigin (AUT: Auckland University of Technology)H-Index: 73
#2Carlene M. M. Lawes (University of Auckland)H-Index: 39
Last. Varsha Parag (University of Auckland)H-Index: 32
view all 5 authors...
Summary This systematic review of population-based studies of the incidence and early (21 days to 1 month) case fatality of stroke is based on studies published from 1970 to 2008. Stroke incidence (incident strokes only) and case fatality from 21 days to 1 month post-stroke were analysed by four decades of study, two country income groups (high-income countries and low to middle income countries, in accordance with the World Bank's country classification) and, when possible, by stroke pathologic...
1,372 CitationsSource
#1Sonia S. Anand (McMaster University)H-Index: 76
#2Shofiqul Islam (McMaster University)H-Index: 27
Last. Salim Yusuf Mb Bs DPhil Frcpc (McMaster University)H-Index: 214
view all 10 authors...
Aims Coronary heart disease (CHD) is a leading cause of death among men and women globally. Women develop CHD about 10 years later than men, yet the reasons for this are unclear. The purpose of this report is to determine if differences in risk factor distributions exist between women and men across various age categories to help explain why women develop acute MI later than men. Methods and results We used the INTERHEART global case–control study including 27 098 participants from 52 countries,...
434 CitationsSource
#1Hugh S. MarkusH-Index: 95
#2Usman KhanH-Index: 7
Last. Paula Jerrard-DunneH-Index: 9
view all 8 authors...
Background— Determining whether the distribution of stroke subtypes differs between ethnic groups is important in understanding the mechanisms of the increased stroke incidence in black patients. Methods and Results— In this study, 600 black and 600 white patients with stroke were prospectively and consecutively recruited to determine differences in stroke subtypes. The pathophysiological Trial of Org 10172 (TOAST) classification was used and compared with a clinical (Oxfordshire Community Strok...
100 CitationsSource
#1Ruth Bonita (University of Auckland)H-Index: 51
#2Robert Beaglehole (University of Auckland)H-Index: 49
See related article, pages 3063–3069. Stroke is a cause of poverty and is caused by poverty. Stroke prevention, along with the prevention of other chronic (noncommunicable) diseases, is a grossly neglected feature of the global development agenda,1 despite the huge economic and health burdens due to stroke. The reasons for this neglect are complex. They include a series of myths which have perpetuated the mistaken notion that stroke and chronic diseases in general are primarily problems of wealt...
56 CitationsSource
#1Ahmed M El Zein (Academy of Medical Sciences, United Kingdom)H-Index: 1
#2Elfateh A Bukhari (Academy of Medical Sciences, United Kingdom)H-Index: 1
Last. Ishag Adam (UofK: University of Khartoum)H-Index: 33
view all 4 authors...
Prospective data were collected on consecutive patients admitted to Khartoum Teaching Hospital with a diagnosis of stroke. Risk factors and clinical characteristics were assessed by neurological examination and computed tomography scan. A total of 128 patients were enrolled in the study, of whom 74 (57.8%) were men. The age (mean±standard deviation) of the patients was 53±18.5 years. Eighty-five (66.4%) and 43 (33.6%) patients had ischaemic and haemorrhagic stroke, respectively. Hypertension, di...
3 CitationsSource
#1Masoor Kamalesh (IU: Indiana University)H-Index: 13
#2Jianzhao Shen (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 1
Last. William M. TierneyH-Index: 76
view all 3 authors...
ABSTRACT Background Stroke is the third leading cause of death in the United States. We investigated racial differences in death after hospital discharge for ischemic stroke in a large cohort of Veterans Health Affairs (VHA) stroke patients. We hypothesized that having access to VA care would ameliorate the excess stroke mortality rates in African-Americans (AA) reported in non-VA studies. Methods Hospital administrative data were used to identify all patients discharged from any VA hospital bet...
12 CitationsSource
#1Ming Liu (Sichuan University)H-Index: 25
#2Bo Wu (Sichuan University)H-Index: 20
Last. Ling-Zhi KongH-Index: 1
view all 6 authors...
Summary In this review, we examine the current status of stroke epidemiology, prevention, and management strategies in mainland China. The main findings suggested that total age-adjusted incidence of first-ever stroke in China is not very different from that in developed countries. Stroke incidence, mortality, and prevalence varied widely among different regions within China, with a noticeable north–south gradient. The proportion of intracerebral haemorrhage was high and reached 55% in one city....
476 CitationsSource
#1Riina Vibo (UT: University of Tartu)H-Index: 7
#2Janika Kõrv (UT: University of Tartu)H-Index: 17
Last. Mai Roose (UT: University of Tartu)H-Index: 9
view all 3 authors...
The aim of the current study was to evaluate the outcome at 1 year following a first-ever stroke based on a population-based registry from 2001 to 2003 in Tartu, Estonia. The outcome of first-ever stroke was assessed in 433 patients by stroke risk factors, demographic data and stroke severity at onset using the Barthel Index (BI) score and the modified Rankin Score (mRS) at seventh day, 6 months and 1 year. Female sex, older age, blood glucose value > 10 mmol/l on admission and more severe strok...
39 CitationsSource
There are a wide variety of causes of stroke and as many different forms of presentation, depending on the area of the brain affected. This article describes how different types of stroke present and outlines the likely outcome for patients for each type.
12 CitationsSource
Cited By45
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Objective: To determine if specific dietary patterns are associated with risk of hypertension, type 2 diabetes mellitus (T2DM), and high BMI in four sites in Peru. Design: We analysed dietary patterns from a cohort of Peruvian adults in four geographical settings using latent class analysis. Associations with prevalence and incidence of hypertension, T2DM and high BMI were assessed using Poisson regression and generalised linear models, adjusted for potential confounders. Setting: Four sites in ...
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#1Fred Stephen Sarfo (KNUST: Kwame Nkrumah University of Science and Technology)H-Index: 22
#1Fred Stephen SarfoH-Index: 5
Last. Bruce OvbiageleH-Index: 56
view all 9 authors...
Abstract Background Clinical trial data indicate that more intensive blood pressure (BP) lowering below standard cut-off targets is associated with lower risks of strokes in the elderly. There is a relative paucity of real-world practice data on this issue, especially among Africans. Objective: To assess BP control rates, its determinants, and whether a lower BP Methods We retrospectively evaluated data, which were prospectively collected as part of a cohort study involving adults with hypertens...
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#1Fred Stephen Sarfo (KNUST: Kwame Nkrumah University of Science and Technology)H-Index: 22
#2Bruce Ovbiagele (UCSF: University of California, San Francisco)H-Index: 56
Last. Morenikeji A. KomolafeH-Index: 12
view all 56 authors...
Objective To characterize risk factors for spontaneous intracerebral hemorrhage (sICH) occurrence and severity among West Africans. Methods The Stroke Investigative Research and Educational Network (SIREN) study is a multicenter case-control study involving 15 sites in Ghana and Nigeria. Patients were adults ≥18 years old with CT-confirmed sICH with age-, sex-, and ethnicity-matched stroke-free community controls. Standard instruments were used to assess vascular, lifestyle, and psychosocial fac...
1 CitationsSource
#1Albert AkpaluH-Index: 13
Last. Mayowa O. OwolabiH-Index: 32
view all 27 authors...
Background and Purpose— The interplay between sex and the dominant risk factors for stroke occurrence in sub-Saharan Africa has not been clearly delineated. We compared the effect sizes of risk factors of stroke by sex among West Africans. Methods— SIREN study (Stroke Investigative Research and Educational Networks) is a case-control study conducted at 15 sites in Ghana and Nigeria. Cases were adults aged >18 years with computerized tomography/magnetic resonance imaging confirmed stroke, and con...
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#1A. M. Zaitoun (Zagazig University)
#2Dorriya Abdel Fattah Elsayed (Zagazig University)
Last. Hanan Ahmed Abdel Gaffar (Zagazig University)
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Background Post stroke delirium is a multifactorial life-threatening process, still poorly understood. The aim of the study was to identify the risk factors associated with the development of delirium in acute stroke patients and detection of the effect of delirium on the short-term prognosis of acute stroke patients.
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#1Fred Stephen Sarfo (KNUST: Kwame Nkrumah University of Science and Technology)H-Index: 22
#2Ohene Opare-Sem (KNUST: Kwame Nkrumah University of Science and Technology)H-Index: 14
Last. Bruce Ovbiagele (MUSC: Medical University of South Carolina)H-Index: 56
view all 7 authors...
Abstract Background HIV infection is an emerging vascular risk factor associated with stroke occurrence. The weight of evidence from sub-Saharan Africa in support of this has accrued from countries with high HIV prevalence. Our objective was to assess the contribution of HIV sero-positivity to the occurrence and outcomes of stroke in a West African country with low HIV prevalence. Methods A case-control study design conducted at a tertiary medical center in Ghana involved in the Stroke Investiga...
4 CitationsSource
#1Fred Stephen Sarfo (KNUST: Kwame Nkrumah University of Science and Technology)H-Index: 22
#2Linda M. Mobula (Johns Hopkins University)H-Index: 5
Last. David Ofori-Adjei (University of Ghana)H-Index: 30
view all 5 authors...
Abstract Background The burden of stroke among hypertensive and diabetic population in sub-Saharan Africa remains high. We sought to identify the risk factors associated with stroke occurrence in these high-risk population groups. Methods A prospective cohort study involving adults with hypertension and or type II diabetes mellitus at 5 public hospitals in Ghana who were stroke-free at enrollment. Patients were followed every 2 months at clinic for 18 months and assessed clinically for first eve...
12 CitationsSource
#1Fred Stephen Sarfo (KNUST: Kwame Nkrumah University of Science and Technology)H-Index: 22
#2Linda M. Mobula (Johns Hopkins University)H-Index: 5
Last. David Ofori-Adjei (University of Ghana)H-Index: 30
view all 10 authors...
Abstract Background Sub-Saharan Africa is currently experiencing a high burden of both chronic kidney disease (CKD) and stroke as a result of a rapid rise in shared common vascular risk factors such as hypertension and diabetes mellitus. However, no previous study has prospectively explored independent associations between CKD and incident stroke occurrence among indigenous Africans. This study sought to fill this knowledge gap. Methods A prospective cohort study involving Ghanaians adults with ...
8 CitationsSource
#1Mayowa O Owolabi (UI: University of Ibadan)H-Index: 1
#2Fred Sarfo (KNUST: Kwame Nkrumah University of Science and Technology)H-Index: 1
Last. Yaw MensahH-Index: 4
view all 87 authors...
Summary Background Sub-Saharan Africa has the highest incidence, prevalence, and fatality from stroke globally. Yet, only little information about context-specific risk factors for prioritising interventions to reduce the stroke burden in sub-Saharan Africa is available. We aimed to identify and characterise the effect of the top modifiable risk factors for stroke in sub-Saharan Africa. Methods The Stroke Investigative Research and Educational Network (SIREN) study is a multicentre, case-control...
26 CitationsSource
#1Yi Dong (Fudan University)H-Index: 3
#2Kun Fang (Fudan University)H-Index: 1
Last. Qiang Dong (Fudan University)H-Index: 19
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BackgroundSeveral stroke outcome and quality control projects have demonstrated the success in stroke care quality improvement through structured process. However, Chinese health-care systems are challenged with its overwhelming numbers of patients, limited resources, and large regional disparities.AimTo improve quality of stroke care to address regional disparities through process improvement.Method and designThe Shanghai Stroke Service System (4S) is established as a regional network for strok...
1 CitationsSource