Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes.
Abstract
Islet amyloid has been recognized as a pathological entity in type 2 diabetes since the turn of the century. It has as its unique component the islet beta-cell peptide islet amyloid polypeptide (IAPP), or amylin, which is cosecreted with insulin. In addition to this unique component, islet amyloid contains other proteins, such as apolipoprotein E and the heparan sulfate proteoglycan perlecan, which are typically observed in other forms of...
Paper Details
Title
Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes.
Published Date
Feb 1, 1999
Journal
Volume
48
Issue
2
Pages
241 - 253
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