A gene-fusion strategy for stoichiometric and co-localized expression of light-gated membrane proteins
Abstract
The precise co-localization and stoichiometric expression of two different light-gated membrane proteins can vastly improve the physiological usefulness of optogenetics for the modulation of cell excitability with light. Here we present a gene-fusion strategy for the stable 1:1 expression of any two microbial rhodopsins in a single polypeptide chain. By joining the excitatory channelrhodopsin-2 with the inhibitory ion pumps halorhodopsin or...
Paper Details
Title
A gene-fusion strategy for stoichiometric and co-localized expression of light-gated membrane proteins
Published Date
Dec 1, 2011
Journal
Volume
8
Issue
12
Pages
1083 - 1088
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