Statistical design of experiments for protein crystal growth and the use of a precrystallization assay
Abstract
Statistical design of crystallization experiments greatly reduces the amount of protein necessary to find conditions for crystal growth and leads naturally to a useful data base for improving crystallization conditions in cases where the initial trials do not produce adequate results. Although it is counterintuitive to vary simultaneously all the factors to be screened, this apparent loss of control over experimental parameters actually costs...
Paper Details
Title
Statistical design of experiments for protein crystal growth and the use of a precrystallization assay
Published Date
Jul 1, 1988
Journal
Volume
90
Issue
1-3
Pages
60 - 73
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Notes
History