p53, the Cellular Gatekeeper for Growth and Division

The p53 gene and its protein product have become the center of intensive study ever since it became clear that slightly more than 50% of human cancers contain mutations in this gene. An extensive database (21Hollstein M Rice K Greenblatt M.S Soussi T Fuchs R Sorlie T Hovig E Smith-Sorensen B Montesano R Harris C.C Database of p53 gene somatic mutations in human tumors and cell lines.Nucleic Acids Res. 1994; 22: 3551-3555PubMed Google Scholar)...