Identification of an Essential Structural Element of Lipid Gating Mechanism in the Transient Receptor Potential Canonical Channel Type 3 (TRPC3)

Transient receptor potential canonical 3 (TRPC3), is highly expressed in neuronal and cardiac tissues, and its importance in development and (patho)physiology of these tissues is well established. So far, our understanding of structure-function relations, specifically in terms of the lipid sensing machinery in this channel protein is incomplete. Using a homology model of TRPC3, based on the recently available structural information on TRPV1, we...