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Abdominal obesity and metabolic syndrome

Published on Dec 1, 2006in Nature43.07
· DOI :10.1038/nature05488
Jean-Pierre Després118
Estimated H-index: 118
(Laval University),
Isabelle Lemieux46
Estimated H-index: 46
Sources
Abstract
Metabolic syndrome is associated with abdominal obesity, blood lipid disorders, inflammation, insulin resistance or full-blown diabetes, and increased risk of developing cardiovascular disease. Proposed criteria for identifying patients with metabolic syndrome have contributed greatly to preventive medicine, but the value of metabolic syndrome as a scientific concept remains controversial. The presence of metabolic syndrome alone cannot predict global cardiovascular disease risk. But abdominal obesity - the most prevalent manifestation of metabolic syndrome - is a marker of 'dysfunctional adipose tissue', and is of central importance in clinical diagnosis. Better risk assessment algorithms are needed to quantify diabetes and cardiovascular disease risk on a global scale.
  • References (91)
  • Citations (2749)
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