Ions from the Hofmeister series and osmolytes: effects on proteins in solution and in the crystallization process.
Abstract
Sephadex G-10 gel sieving chromatography, Jones-Dole viscosity B coefficients, and solution neutron and X-ray diffraction are used to show that small ions of high charge density (e.g., sulfate, phosphate, the carboxylate, sodium, and fluoride) are strongly hydrated (kosmotropes) whereas large monovalent ions of low charge density (e.g., ammonium, chloride, potassium, and the positively charged amino acid side chains) are weakly hydrated...
Paper Details
Title
Ions from the Hofmeister series and osmolytes: effects on proteins in solution and in the crystallization process.
Published Date
Nov 1, 2004
Journal
Volume
34
Issue
3
Pages
300 - 311
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Notes
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