Therapeutic potential of self‐antigen‐specific CD4⁺CD25⁺ regulatory T cells selected in vitro from a polyclonal repertoire

CD4 + CD25 + regulatory T cells (T reg ) play a major role in the prevention of autoimmune diseases. Converging evidence indicates that T reg specific for self‐antigens expressed by target tissues have a greater therapeutic potential than polyclonal T reg . Therefore, the selective expansion of rare self‐antigen‐specific T reg naturally present in a polyclonal repertoire of T reg is of major importance. In this work, we investigated the...