Ribonucleotides in DNA: Origins, repair and consequences
Abstract
While primordial life is thought to have been RNA-based (Cech, Cold Spring Harbor Perspect. Biol. 4 (2012) a006742), all living organisms store genetic information in DNA, which is chemically more stable. Distinctions between the RNA and DNA worlds and our views of "DNA" synthesis continue to evolve as new details emerge on the incorporation, repair and biological effects of ribonucleotides in DNA genomes of organisms from bacteria through...
Paper Details
Title
Ribonucleotides in DNA: Origins, repair and consequences
Published Date
Jul 1, 2014
Journal
Volume
19
Pages
27 - 37
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