Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host
Abstract
Although at the genetic level cancer is caused by diverse mutations, epigenetic modifications are characteristic of all cancers, from apparently normal precursor tissue to advanced metastatic disease, and these epigenetic modifications drive tumour cell heterogeneity. We propose a unifying model of cancer in which epigenetic dysregulation allows rapid selection for tumour cell survival at the expense of the host. Mechanisms involve both genetic...
Paper Details
Title
Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host
Published Date
Jun 13, 2013
Journal
Volume
13
Issue
7
Pages
497 - 510
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History