AMPK is required for PM2.5-induced autophagy in human lung epithelial A549 cells.
Abstract
The aim is to investigate the molecular mechanisms underlying the PM2.5-induced autophagy in human lung cancer epithelial cells (A549). The effects of the PM2.5 on morphological and biochemical markers of autophagy in A549 were analyzed by electron microscopy, GFP-LC3 puncta was observed by confocal fluorescence microscope. The effects of phosphorylation of AMPK, mTOR, AKT, ERK, JNK, and p53 on LC3II in A549 were observed following PM2.5...
Paper Details
Title
AMPK is required for PM2.5-induced autophagy in human lung epithelial A549 cells.
Published Date
Jan 1, 2015
Journal
Volume
8
Issue
1
Pages
58 - 72
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