Real-Time Imaging Reveals that HIV-1 Vpr Dissociates from the Core and Accumulates in the Nucleus after Viral Fusion
Abstract
Viral protein R (Vpr) is an HIV-1 accessory protein that associates with capsids during viral assembly and is important for infections in non-dividing cells. Vpr functions in host cells include induction of G2 cell-cycle arrest, and regulation of cellular proliferation and apoptosis. Vpr has two nuclear localization sequences that direct its transport to the nucleus. Fluorescently labeled Vpr (YFP-Vpr) is widely used to visualize HIV-1 cores in...
Paper Details
Title
Real-Time Imaging Reveals that HIV-1 Vpr Dissociates from the Core and Accumulates in the Nucleus after Viral Fusion
Published Date
Jan 1, 2015
Journal
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