Match!

Subspecialization in the human posterior medial cortex

Published on Feb 1, 2015in NeuroImage5.812
· DOI :10.1016/j.neuroimage.2014.11.009
Danilo Bzdok24
Estimated H-index: 24
(HHU: University of Düsseldorf),
Adrian Heeger1
Estimated H-index: 1
(HHU: University of Düsseldorf)
+ 6 AuthorsSimon B. Eickhoff86
Estimated H-index: 86
(HHU: University of Düsseldorf)
Abstract
Abstract The posterior medial cortex (PMC) is particularly poorly understood. Its neural activity changes have been related to highly disparate mental processes. We therefore investigated PMC properties with a data-driven exploratory approach. First, we subdivided the PMC by whole-brain coactivation profiles. Second, functional connectivity of the ensuing PMC regions was compared by task-constrained meta-analytic coactivation mapping (MACM) and task-unconstrained resting-state correlations (RSFC). Third, PMC regions were functionally described by forward/reverse functional inference. A precuneal cluster was mostly connected to the intraparietal sulcus, frontal eye fields, and right temporo-parietal junction; associated with attention and motor tasks. A ventral posterior cingulate cortex (PCC) cluster was mostly connected to the ventromedial prefrontal cortex and middle left inferior parietal cortex (IPC); associated with facial appraisal and language tasks. A dorsal PCC cluster was mostly connected to the dorsomedial prefrontal cortex, anterior/posterior IPC, posterior midcingulate cortex, and left dorsolateral prefrontal cortex; associated with delay discounting. A cluster in the retrosplenial cortex was mostly connected to the anterior thalamus and hippocampus. Furthermore, all PMC clusters were congruently coupled with the default mode network according to task-unconstrained but not task-constrained connectivity. We thus identified distinct regions in the PMC and characterized their neural networks and functional implications.
  • References (180)
  • Citations (92)
📖 Papers frequently viewed together
5,413 Citations
1,283 Citations
2,842 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References180
Newest
#1Simon B. Eickhoff (HHU: University of Düsseldorf)H-Index: 86
#2Angela R. Laird (FIU: Florida International University)H-Index: 67
Last. L. HenselH-Index: 2
view all 5 authors...
The human dorsomedial prefrontal cortex (dmPFC) has been implicated in various complex cognitive processes, including social cognition. To unravel its functional organization, we assessed the dmPFC’s regional heterogeneity, connectivity patterns, and functional profiles. First, the heterogeneity of a dmPFC seed, engaged during social processing, was investigated by assessing local differences in whole-brain coactivation profiles. Second, functional connectivity of the ensuing dmPFC clusters was ...
83 CitationsSource
#1L. Hensel (RWTH Aachen University)H-Index: 2
#2Danilo BzdokH-Index: 24
Last. Simon B. Eickhoff (HHU: University of Düsseldorf)H-Index: 86
view all 5 authors...
Functional neuroimaging research on the neural basis of social evaluation has traditionally focused on face perception paradigms. Thus, little is known about the neurobiology of social evaluation processes based on auditory cues, such as voices. To investigate the top-down effects of social trait judgments on voices, hemodynamic responses of 44 healthy participants were measured during social trait (trustworthiness [TR] and attractiveness [AT]), emotional (happiness, HA), and cognitive (age, AG)...
10 CitationsSource
#1Sebastian BludauH-Index: 9
#2Simon B. Eickhoff (HHU: University of Düsseldorf)H-Index: 86
Last. Katrin Amunts (HHU: University of Düsseldorf)H-Index: 74
view all 9 authors...
Abstract The frontal pole has more expanded than any other part in the human brain as compared to our ancestors. It plays an important role for specifically human behavior and cognitive abilities, e.g. action selection ( Kovach et al., 2012 ). Evidence about divergent functions of its medial and lateral part has been provided, both in the healthy brain and in psychiatric disorders. The anatomical correlates of such functional segregation, however, are still unknown due to a lack of stereotaxic, ...
99 CitationsSource
#1Yukihito YomogidaH-Index: 12
#2Motoaki SugiuraH-Index: 35
Last. Ryuta KawashimaH-Index: 60
view all 5 authors...
Event simulation (ES) is the situational inference process in which perceived event features such as objects, agents, and actions are associated in the brain to represent the whole situation. ES provides a common basis for various cognitive processes, such as perceptual prediction, situational understanding/prediction, and social cognition (such as mentalizing/trait inference). Here, functional magnetic resonance imaging was used to elucidate the neural substrates underlying important subdivisio...
2 CitationsSource
#1Yaqin Zhang (University of Electronic Science and Technology of China)H-Index: 2
#2Lingzhong Fan (CAS: Chinese Academy of Sciences)H-Index: 20
Last. Tianzi Jiang (CAS: Chinese Academy of Sciences)H-Index: 67
view all 8 authors...
Regional structural and functional variations in the posteromedial cortex (PMC) have been found in both animals and humans, strongly suggesting the presence of subdivisions. However, there is no consensus on how to subdivide the human PMC. Here, we investigated the anatomical parcellation scheme and the connectivity pattern of each subdivision of the human PMC using diffusion tensor imaging data from 2 independent groups of volunteers. The parcellation analyses of the 2 datasets consistently dem...
54 CitationsSource
#1Robert Leech (Imperial College London)H-Index: 39
#2David J. Sharp (Imperial College London)H-Index: 27
The posterior cingulate cortex is a highly connected and metabolically active brain region. Recent studies suggest it has an important cognitive role, although there is no consensus about what this is. The region is typically discussed as having a unitary function because of a common pattern of relative deactivation observed during attentionally demanding tasks. One influential hypothesis is that the posterior cingulate cortex has a central role in supporting internally-directed cognition. It is...
772 CitationsSource
#1Mareike ClosH-Index: 11
#2Katrin AmuntsH-Index: 74
Last. Simon B. Eickhoff (HHU: University of Düsseldorf)H-Index: 86
view all 5 authors...
Cytoarchitectonic area 44 of Broca's region in the left inferior frontal gyrus is known to be involved in several functional domains including language, action and music processing. We investigated whether this functional heterogeneity is reflected in distinct modules within cytoarchitectonically defined left area 44 using meta-analytic connectivity-based parcellation (CBP). This method relies on identifying the whole-brain co-activation pattern for each area 44 voxel across a wide range of func...
89 CitationsSource
#1Danilo Bzdok (RWTH Aachen University)H-Index: 24
#2Angela R. Laird (University of Texas Health Science Center at San Antonio)H-Index: 67
Last. Simon B. EickhoffH-Index: 86
view all 5 authors...
Although the amygdala complex is a brain area critical for human behavior, knowledge of its subspecialization is primarily derived from experiments in animals. We here employed methods for large-scale data mining to perform a connectivity-derived parcellation of the human amygdala based on whole-brain coactivation patterns computed for each seed voxel. Voxels within the histologically defined human amygdala were clustered into distinct groups based on their brain-wide coactivation maps. Using th...
181 CitationsSource
#1Danilo Bzdok (University of Texas Health Science Center at San Antonio)H-Index: 24
#2Robert Langner (University of Texas Health Science Center at San Antonio)H-Index: 30
Last. Simon B. Eickhoff (University of Texas Health Science Center at San Antonio)H-Index: 86
view all 10 authors...
The right temporo-parietal junction (RTPJ) is consistently implicated in two cognitive domains, attention and social cognitions. We conducted multi-modal connectivity-based parcellation to investigate potentially separate functional modules within RTPJ implementing this cognitive dualism. Both task-constrained meta-analytic coactivation mapping and task-free resting-state connectivity analysis independently identified two distinct clusters within RTPJ, subsequently characterized by network mappi...
141 CitationsSource
#1Edna C. CieslikH-Index: 16
#2Karl ZillesH-Index: 123
Last. Simon B. EickhoffH-Index: 86
view all 10 authors...
The dorsolateral prefrontal cortex (DLPFC) has consistently been implicated in cognitive control of motor behavior. There is, however, considerable variability in the exact location and extension of these activations across functional magnetic resonance imaging (fMRI) experiments. This poses the question of whether this variability reflects sampling error and spatial uncertainty in fMRI experiments or structural and functional heterogeneity of this region. This study shows that the right DLPFC a...
193 CitationsSource
Cited By92
Newest
#1Henry W. Chase (University of Pittsburgh)H-Index: 23
#2Anthony A. Grace (University of Pittsburgh)H-Index: 90
Last. Simon B. Eickhoff (HHU: University of Düsseldorf)H-Index: 86
view all 5 authors...
Ventromedial regions of the frontal lobe (vmFL) are thought to play a key role in decision-making and emotional regulation. However, aspects of this area's functional organization, including the presence of a multiple subregions, their functional and anatomical connectivity, and the cross-species homologies of these subregions with those of other species, remain poorly understood. To address this uncertainty, we employed a two-stage parcellation of the region to identify six distinct structures ...
Source
#1Wasim Khan (University of Melbourne)H-Index: 5
#2Ali Amad ('KCL': King's College London)H-Index: 13
Last. Amy Brodtmann (Box Hill Hospital)H-Index: 18
view all 10 authors...
The posteromedial cortex (PMC) is a key region involved in the development and progression of Alzheimer's disease (AD). Previous studies have demonstrated a heterogenous functional architecture of the region that is composed of discrete functional modules reflecting a complex pattern of functional connectivity. However, little is understood about the mechanisms underpinning this complex network architecture in neurodegenerative disease, and the differential vulnerability of connectivity-based su...
Source
#1Wei Zhang (Radboud University Nijmegen)H-Index: 17
#2Alberto Llera (Radboud University Nijmegen)H-Index: 7
Last. Karin Roelofs (Radboud University Nijmegen)H-Index: 33
view all 8 authors...
Acute stress induces large-scale neural reorganization with relevance to stress-related psychopathology. Here, we applied a novel supervised machine learning method, combining the strengths of a priori theoretical insights with a data-driven approach, to identify which connectivity changes are most prominently associated with a state of acute stress and individual differences therein. Resting-state functional magnetic resonance imaging scans were taken from 334 healthy participants (79 females) ...
Source
#1Jessica S. Flannery (FIU: Florida International University)H-Index: 2
#2Michael C. Riedel (FIU: Florida International University)H-Index: 9
Last. Matthew T. Sutherland (FIU: Florida International University)H-Index: 17
view all 8 authors...
Reward learning is a ubiquitous cognitive mechanism guiding adaptive choices and behaviors, and when impaired, can lead to considerable mental health consequences. Reward-related functional neuroimaging studies have begun to implicate networks of brain regions essential for processing various peripheral influences (e.g., risk, subjective preference, delay, social context) involved in the multifaceted reward processing construct. To provide a more complete neurocognitive perspective on reward pro...
Source
#1Niels Reuter (HHU: University of Düsseldorf)H-Index: 2
Last. Kaustubh PatilH-Index: 8
view all 8 authors...
Regional connectivity-based parcellation (rCBP) is a widely used procedure for investigating the structural and functional differentiation within a region of interest (ROI) based on its long-range connectivity. No standardized software or guidelines currently exist for applying rCBP, making the method only accessible to those who develop their own tools. As such, there exists a discrepancy between the laboratories applying the procedure each with their own software solutions, making it difficult...
1 CitationsSource
#1Paul A. Frewen (UWO: University of Western Ontario)H-Index: 34
#2Matthias L. Schroeter (MPG: Max Planck Society)H-Index: 38
Last. Kwabena Kusi-Mensah (Komfo Anokye Teaching Hospital)H-Index: 1
view all 15 authors...
Abstract We review neuroimaging research investigating self-referential processing (SRP), that is, how we respond to stimuli that reference ourselves, prefaced by a lexical-thematic analysis of words indicative of “self-feelings”. We consider SRP as occurring verbally (V-SRP) and non-verbally (NV-SRP), both in the controlled, “top-down” form of introspective and interoceptive tasks, respectively, as well as in the “bottom-up” spontaneous or automatic form of “mind wandering” and “body wandering”...
Source
#1Parker G. Allan (University of Oklahoma Health Sciences Center)H-Index: 1
#2Robert G. Briggs (SC: University of Southern California)H-Index: 1
Last. Michael E. SughrueH-Index: 38
view all 11 authors...
Abstract Introduction The ventral attention network (VAN) is an important mediator of stimulus-driven attention. Multiple cortical areas, such as the middle and inferior frontal gyri, anterior insula, inferior parietal lobule, and temporo-parietal junction have been linked in this processing. However, knowledge of network connectivity has been devoid of structural specificity. Methods Using relevant task-based fMRI studies, an activation likelihood estimation (ALE) of the VAN was generated Regio...
2 CitationsSource
#1Charlotte MurphyH-Index: 7
#2Giulia L. PoerioH-Index: 9
Last. Jonathan SmallwoodH-Index: 53
view all 9 authors...
Source
#1Charlotte MurphyH-Index: 7
#2Giulia L. PoerioH-Index: 9
Last. Jonathan SmallwoodH-Index: 53
view all 9 authors...
Neural activity within the default mode network (DMN) is widely assumed to relate to processing during off-task states, however it remains unclear whether this association emerges from a shared role in self or social content that is common in these conditions. In the current study, we examine the possibility that the role of the DMN in ongoing thought emerges from contributions to specific features of off-task experience such as self-relevant or social content. A group of participants described ...
Source
#1Jessica S. Flannery (FIU: Florida International University)H-Index: 2
#2Michael C. Riedel (FIU: Florida International University)H-Index: 9
Last. Matthew T. Sutherland (FIU: Florida International University)H-Index: 17
view all 8 authors...
Reward learning is a ubiquitous cognitive mechanism guiding adaptive choices and behaviors, and when impaired, can lead to considerable mental health consequences. Reward-related functional neuroimaging studies have begun to implicate networks of brain regions essential for processing various peripheral influences (e.g., risk, subjective preference, delay, social context) involved in the multifaceted reward processing construct. To provide a more complete neurocognitive perspective on reward pro...
Source