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Subspecialization in the human posterior medial cortex

Published on Feb 1, 2015in NeuroImage5.81
· DOI :10.1016/j.neuroimage.2014.11.009
Danilo Bzdok22
Estimated H-index: 22
(HHU: University of Düsseldorf),
Adrian Heeger1
Estimated H-index: 1
(HHU: University of Düsseldorf)
+ 6 AuthorsSimon B. Eickhoff83
Estimated H-index: 83
(HHU: University of Düsseldorf)
Cite
Abstract
Abstract The posterior medial cortex (PMC) is particularly poorly understood. Its neural activity changes have been related to highly disparate mental processes. We therefore investigated PMC properties with a data-driven exploratory approach. First, we subdivided the PMC by whole-brain coactivation profiles. Second, functional connectivity of the ensuing PMC regions was compared by task-constrained meta-analytic coactivation mapping (MACM) and task-unconstrained resting-state correlations (RSFC). Third, PMC regions were functionally described by forward/reverse functional inference. A precuneal cluster was mostly connected to the intraparietal sulcus, frontal eye fields, and right temporo-parietal junction; associated with attention and motor tasks. A ventral posterior cingulate cortex (PCC) cluster was mostly connected to the ventromedial prefrontal cortex and middle left inferior parietal cortex (IPC); associated with facial appraisal and language tasks. A dorsal PCC cluster was mostly connected to the dorsomedial prefrontal cortex, anterior/posterior IPC, posterior midcingulate cortex, and left dorsolateral prefrontal cortex; associated with delay discounting. A cluster in the retrosplenial cortex was mostly connected to the anterior thalamus and hippocampus. Furthermore, all PMC clusters were congruently coupled with the default mode network according to task-unconstrained but not task-constrained connectivity. We thus identified distinct regions in the PMC and characterized their neural networks and functional implications.
  • References (178)
  • Citations (78)
Cite
References178
Newest
Published on Jan 1, 2016in Cerebral Cortex5.44
Simon B. Eickhoff83
Estimated H-index: 83
(HHU: University of Düsseldorf),
A. R. Laird66
Estimated H-index: 66
(FIU: Florida International University)
+ 2 AuthorsL. Hensel2
Estimated H-index: 2
The human dorsomedial prefrontal cortex (dmPFC) has been implicated in various complex cognitive processes, including social cognition. To unravel its functional organization, we assessed the dmPFC’s regional heterogeneity, connectivity patterns, and functional profiles. First, the heterogeneity of a dmPFC seed, engaged during social processing, was investigated by assessing local differences in whole-brain coactivation profiles. Second, functional connectivity of the ensuing dmPFC clusters was ...
Published on May 1, 2015in Cerebral Cortex5.44
L. Hensel2
Estimated H-index: 2
(RWTH Aachen University),
Danilo Bzdok22
Estimated H-index: 22
+ 2 AuthorsSimon B. Eickhoff83
Estimated H-index: 83
(HHU: University of Düsseldorf)
Functional neuroimaging research on the neural basis of social evaluation has traditionally focused on face perception paradigms. Thus, little is known about the neurobiology of social evaluation processes based on auditory cues, such as voices. To investigate the top-down effects of social trait judgments on voices, hemodynamic responses of 44 healthy participants were measured during social trait (trustworthiness [TR] and attractiveness [AT]), emotional (happiness, HA), and cognitive (age, AG)...
Published on Jun 1, 2014in NeuroImage5.81
Sebastian Bludau8
Estimated H-index: 8
,
Simon B. Eickhoff83
Estimated H-index: 83
(HHU: University of Düsseldorf)
+ 6 AuthorsKatrin Amunts72
Estimated H-index: 72
(HHU: University of Düsseldorf)
Abstract The frontal pole has more expanded than any other part in the human brain as compared to our ancestors. It plays an important role for specifically human behavior and cognitive abilities, e.g. action selection ( Kovach et al., 2012 ). Evidence about divergent functions of its medial and lateral part has been provided, both in the healthy brain and in psychiatric disorders. The anatomical correlates of such functional segregation, however, are still unknown due to a lack of stereotaxic, ...
Published on May 2, 2014in PLOS ONE2.78
Yukihito Yomogida11
Estimated H-index: 11
,
Motoaki Sugiura27
Estimated H-index: 27
+ 2 AuthorsRyuta Kawashima60
Estimated H-index: 60
Event simulation (ES) is the situational inference process in which perceived event features such as objects, agents, and actions are associated in the brain to represent the whole situation. ES provides a common basis for various cognitive processes, such as perceptual prediction, situational understanding/prediction, and social cognition (such as mentalizing/trait inference). Here, functional magnetic resonance imaging was used to elucidate the neural substrates underlying important subdivisio...
Published on Mar 1, 2014in Cerebral Cortex5.44
Yaqin Zhang2
Estimated H-index: 2
(University of Electronic Science and Technology of China),
Lingzhong Fan20
Estimated H-index: 20
(CAS: Chinese Academy of Sciences)
+ 5 AuthorsTianzi Jiang63
Estimated H-index: 63
(CAS: Chinese Academy of Sciences)
Regional structural and functional variations in the posteromedial cortex (PMC) have been found in both animals and humans, strongly suggesting the presence of subdivisions. However, there is no consensus on how to subdivide the human PMC. Here, we investigated the anatomical parcellation scheme and the connectivity pattern of each subdivision of the human PMC using diffusion tensor imaging data from 2 independent groups of volunteers. The parcellation analyses of the 2 datasets consistently dem...
Published on Jan 1, 2014in Brain11.81
Robert Leech38
Estimated H-index: 38
(Imperial College London),
David J. Sharp32
Estimated H-index: 32
(Imperial College London)
The posterior cingulate cortex is a highly connected and metabolically active brain region. Recent studies suggest it has an important cognitive role, although there is no consensus about what this is. The region is typically discussed as having a unitary function because of a common pattern of relative deactivation observed during attentionally demanding tasks. One influential hypothesis is that the posterior cingulate cortex has a central role in supporting internally-directed cognition. It is...
Published on Dec 1, 2013in NeuroImage5.81
Mareike Clos11
Estimated H-index: 11
,
Katrin Amunts72
Estimated H-index: 72
+ 2 AuthorsSimon B. Eickhoff83
Estimated H-index: 83
(HHU: University of Düsseldorf)
Cytoarchitectonic area 44 of Broca's region in the left inferior frontal gyrus is known to be involved in several functional domains including language, action and music processing. We investigated whether this functional heterogeneity is reflected in distinct modules within cytoarchitectonically defined left area 44 using meta-analytic connectivity-based parcellation (CBP). This method relies on identifying the whole-brain co-activation pattern for each area 44 voxel across a wide range of func...
Published on Dec 1, 2013in Human Brain Mapping4.55
Danilo Bzdok22
Estimated H-index: 22
(RWTH Aachen University),
A. R. Laird66
Estimated H-index: 66
(University of Texas Health Science Center at San Antonio)
+ 2 AuthorsSimon B. Eickhoff83
Estimated H-index: 83
Although the amygdala complex is a brain area critical for human behavior, knowledge of its subspecialization is primarily derived from experiments in animals. We here employed methods for large-scale data mining to perform a connectivity-derived parcellation of the human amygdala based on whole-brain coactivation patterns computed for each seed voxel. Voxels within the histologically defined human amygdala were clustered into distinct groups based on their brain-wide coactivation maps. Using th...
Published on Nov 1, 2013in Cerebral Cortex5.44
Edna C. Cieslik16
Estimated H-index: 16
,
Karl Zilles121
Estimated H-index: 121
+ 7 AuthorsSimon B. Eickhoff83
Estimated H-index: 83
The dorsolateral prefrontal cortex (DLPFC) has consistently been implicated in cognitive control of motor behavior. There is, however, considerable variability in the exact location and extension of these activations across functional magnetic resonance imaging (fMRI) experiments. This poses the question of whether this variability reflects sampling error and spatial uncertainty in fMRI experiments or structural and functional heterogeneity of this region. This study shows that the right DLPFC a...
Published on Nov 1, 2013in NeuroImage5.81
Danilo Bzdok22
Estimated H-index: 22
(University of Texas Health Science Center at San Antonio),
Robert Langner28
Estimated H-index: 28
(University of Texas Health Science Center at San Antonio)
+ 7 AuthorsSimon B. Eickhoff83
Estimated H-index: 83
(University of Texas Health Science Center at San Antonio)
The right temporo-parietal junction (RTPJ) is consistently implicated in two cognitive domains, attention and social cognitions. We conducted multi-modal connectivity-based parcellation to investigate potentially separate functional modules within RTPJ implementing this cognitive dualism. Both task-constrained meta-analytic coactivation mapping and task-free resting-state connectivity analysis independently identified two distinct clusters within RTPJ, subsequently characterized by network mappi...
Cited By78
Newest
Published on Oct 1, 2019in NeuroImage5.81
P. Andersson14
Estimated H-index: 14
(Stockholm University),
Flavio Ragni (University of Trento), Angelika Lingnau18
Estimated H-index: 18
(University of Regensburg)
Abstract Visual imagery has been suggested to recruit occipital cortex via feedback projections from fronto-parietal regions, suggesting that these feedback projections might be exploited to boost recruitment of occipital cortex by means of real-time neurofeedback. To test this prediction, we instructed a group of healthy participants to perform peripheral visual imagery while they received real-time auditory feedback based on the BOLD signal from either early visual cortex or the medial superio...
Published on Jun 1, 2019in NeuroImage5.81
Adrian W. Gilmore14
Estimated H-index: 14
(WashU: Washington University in St. Louis),
Steven M. Nelson20
Estimated H-index: 20
(Baylor University)
+ 12 AuthorsCatherine R. Hoyt2
Estimated H-index: 2
(WashU: Washington University in St. Louis)
Abstract fMRI studies of human memory have identified a “parietal memory network” (PMN) that displays distinct responses to novel and familiar stimuli, typically deactivating during initial encoding but robustly activating during retrieval. The small size of PMN regions, combined with their proximity to the neighboring default mode network, makes a targeted assessment of their responses in highly sampled subjects important for understanding information processing within the network. Here, we des...
Published on 2019in bioRxiv
Cooperation upholds life in organized societies, but its neurobiological mechanisms remain unresolved. Recent theoretical analyses have contrasted cooperation by its fast versus slower modes of decision making. This raises the question of the neural timescales involved in the integration of decision-related information, and of the participating neural circuits. Using time-resolved electroencephalography (EEG) methods, we characterized relevant neural signatures of feedback processing at the iter...
Published on Sep 4, 2019in Topics in Cognitive Science2.05
David Stawarczyk (University of Liège), Matthew A. Bezdek5
Estimated H-index: 5
(UW: University of Washington),
Jeffrey M. Zacks42
Estimated H-index: 42
(UW: University of Washington)
Published on Jul 10, 2019in Experimental Brain Research1.88
Jessica N. Busler2
Estimated H-index: 2
(AU: Auburn University),
Julio A. Yanes3
Estimated H-index: 3
(AU: Auburn University)
+ 2 AuthorsJennifer L. Robinson22
Estimated H-index: 22
(AU: Auburn University)
The posterior cingulate cortex (PCC) has been implicated in a host of cognitive and behavioral processes in addition to serving as a central hub in the default mode network (DMN). Moreover, the PCC has been shown to be involved in a range of psychiatric and neurological disorders. However, very little is known about the specific activated/deactivated functional profiles of the PCC. Here, we employed a dual analytic approach using robust quantitative meta-analytical connectivity modeling (MACM) a...
Published on Jul 15, 2019in eLife7.55
Edward Silson7
Estimated H-index: 7
(NIH: National Institutes of Health),
Adam Steel4
Estimated H-index: 4
(NIH: National Institutes of Health)
+ 2 AuthorsChris I. Baker36
Estimated H-index: 36
(NIH: National Institutes of Health)
Published on Jul 12, 2019in bioRxiv
Wasim Khan (Florey Institute of Neuroscience and Mental Health), Ali Amad12
Estimated H-index: 12
('KCL': King's College London)
+ 7 AuthorsAmy Brodtmann16
Estimated H-index: 16
The posteromedial cortex (PMC) is a key region involved in the development and progression of Alzheimer disease (AD). Previous studies have demonstrated a heterogenous functional architecture of the region, with different subdivisions reflecting distinct connectivity profiles. However, little is understood about PMC functional connectivity and its differential vulnerability to AD pathogenesis. Using a data-driven approach, we applied a constrained independent component analysis (ICA) on healthy ...
Published on 2019in Human Brain Mapping4.55
Alison G. Costigan1
Estimated H-index: 1
(Cardiff University),
Katja Umla-Runge4
Estimated H-index: 4
(Cardiff University)
+ 3 AuthorsKim Samantha Graham50
Estimated H-index: 50
(Cardiff University)
Precuneus/posterior cingulate cortex (PCu/PCC) are key components of a midline network, activated during rest but also in tasks that involve construction of scene or situation models. Despite growing interest in PCu/PCC functional alterations in disease and disease risk, the underlying neurochemical modulators of PCu/PCC's task‐evoked activity are largely unstudied. Here, a multimodal imaging approach was applied to investigate whether interindividual differences in PCu/PCC fMRI activity, elicit...
Published on May 21, 2019in Frontiers in Psychology2.13
Emiliano Bruner , Ben Gleeson1
Estimated H-index: 1
(ANU: Australian National University),
Ben T. Gleeson
Published on Apr 17, 2019in bioRxiv
Charlotte Murphy6
Estimated H-index: 6
(Ebor: University of York),
Giulia L. Poerio8
Estimated H-index: 8
(University of Sheffield)
+ 6 AuthorsJonathan Smallwood49
Estimated H-index: 49
(Ebor: University of York)
Neural activity within the default mode network (DMN) is widely assumed to relate to processing during off-task states, however it remains unclear whether this association emerges from a shared role in self or social cognition. In the current study, we examine the possibility that the role of the DMN in ongoing thought emerges from contributions to specific features of off-task experience such as self-relevant or social content. A group of participants described their experiences while performin...
View next paperPrecuneus shares intrinsic functional architecture in humans and monkeys