CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool

Volume: 10, Issue: 4
Published: Apr 24, 2015
Abstract
Engineering of the CRISPR/Cas9 system has opened a plethora of new opportunities for site-directed mutagenesis and targeted genome modification. Fundamental to this is a stretch of twenty nucleotides at the 5’ end of a guide RNA that provides specificity to the bound Cas9 endonuclease. Since a sequence of twenty nucleotides can occur multiple times in a given genome and some mismatches seem to be accepted by the CRISPR/Cas9 complex, an efficient...
Paper Details
Title
CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool
Published Date
Apr 24, 2015
Journal
Volume
10
Issue
4
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