Chromatin organization is a major influence on regional mutation rates in human cancer cells
Abstract
Cancer genome sequencing provides the first direct information on how mutation rates vary across the human genome in somatic cells. Testing diverse genetic and epigenetic features, here we show that mutation rates in cancer genomes are strikingly related to chromatin organization. Indeed, at the megabase scale, a single feature—levels of the heterochromatin-associated histone modification H3K9me3—can account for more than 40% of mutation-rate...
Paper Details
Title
Chromatin organization is a major influence on regional mutation rates in human cancer cells
Published Date
Jul 22, 2012
Journal
Volume
488
Issue
7412
Pages
504 - 507
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