Modeling and Simulation of Preclinical Cardiac Safety: Towards an Integrative Framework

Volume: 24, Issue: 1, Pages: 76 - 90
Published: Jan 1, 2009
Abstract
Despite an impressive battery of preclinical cardiac electrophysiology experimental models and the assessment of QT during clinical trials, the risk of Torsades de Pointes (TdP), a potentially lethal ventricular arrhythmia, remains among the common reasons for drug market withdrawal or lack of approval. Due to the low prevalence of TdP, development of statistical evidence that other clinical markers could be better predictors of TdP has proven...
Paper Details
Title
Modeling and Simulation of Preclinical Cardiac Safety: Towards an Integrative Framework
Published Date
Jan 1, 2009
Volume
24
Issue
1
Pages
76 - 90
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