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Experimental diuretic effects of Rosmarinus officinalis and Centaurium erythraea

Published on Aug 1, 2000in Journal of Ethnopharmacology 3.12
· DOI :10.1016/S0378-8741(00)00184-7
Mounsif Haloui3
Estimated H-index: 3
(SIDI),
Liliane Louedec28
Estimated H-index: 28
(French Institute of Health and Medical Research)
+ 1 AuthorsBadiaa Lyoussi21
Estimated H-index: 21
(SIDI)
Abstract
Herbal remedies are widely used in Moroccan pharmacopoeia. We assessed the diuretic effect of two medicinal plants: Rosmarinus officinalis L., Labiatae, and Centaurium erythraea L., Gentianaceae, both reputed for the treatment of urinary ailments. To determine the action of these herbs on urinary volume (UV) and the excretion of sodium (UNaV), potassium (UKV), and chloride (UClV), the aqueous extracts of both plants were administered daily to Wistar rats for 1 week. The concentration of electrolytes and urea in plasma and creatinine clearance were also investigated. Daily oral administration of the aqueous extracts of R. officinalis and C. erythraea at the dose of 10 ml/kg of 8 or 16% extract in distilled water significantly enhanced diuresis in rats compared to the control group from the fifth day of treatment. For R. officinalis at the dose of 8% the peak of urinary excretion of sodium, potassium and chloride was reached after 6 days of treatment (P<0.001). The aqueous extract of of R. officinalis at the dose of 16% did not significantly affect the excretion of water and electrolytes over a similar period but slight increases in urinary excretion of sodium and chloride on the seventh day and of potassium on the sixth day (P<0.05) were observed. No increase was recorded for 24 h urinary excretion of Na+, K+ and Cl− during the first 4 days of treatment for the groups treated with C. erythraea at the doses of 8 and 16% whereas their effects on the same parameters were highly significant thereafter. No change was observed in plasma electrolytes and urea in any group, except for a decrease in sodium and chloride concentration in the group treated with 16% of R. officinalis. A decrease in creatinine clearance was demonstrated after treatment with 8% of R. officinalis and C. erythraea . Our findings demonstrate a diuretic effect of aqueous extracts of R. officinalis L. and C. erythraea L. with the most effective dose for water and electrolyte excretion being 8% for both plants.
  • References (17)
  • Citations (115)
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References17
Published on Jan 1, 1991in Pharmaceutica Acta Helvetiae
Lamaison Jl2
Estimated H-index: 2
,
Petitjean-Freytet C2
Estimated H-index: 2
,
Carnat A2
Estimated H-index: 2
156 Citations
Published on Mar 1, 1949in Nature 41.58
W. O. James1
Estimated H-index: 1
34 Citations Source Cite
Published on May 1, 1991in Journal of Ethnopharmacology 3.12
M. Aqel11
Estimated H-index: 11
(University of Jordan)
Abstract The effects of the volatile oil of Rosmarinus officinalis leaves on the tracheal smooth muscle of rabbit and guinea pig were tested in vitro using isolated tracheal strips. The volatile oil of R. officinalis leaves inhibited the contractions of rabbit tracheal smooth muscle induced by acetylcholine stimulation and the contractions of guinea pig tracheal smooth muscle induced by histamine stimulation. Also, the volatile oil inhibited the contractions of rabbit and guinea pig tracheal smo...
44 Citations Source Cite
Published on Aug 1, 1982in Journal of the American Oil Chemists' Society 1.60
James Wu1
Estimated H-index: 1
(Rutgers University),
Min-Hsiung Lee3
Estimated H-index: 3
(Rutgers University)
+ 1 AuthorsStephen S. Chang28
Estimated H-index: 28
(Rutgers University)
A natural antioxidant extract with activity greater than BHA and equal to BHT was isolated from rosemary leaves. The extract was separated into 7 primary fractions with liquid chromatography, using silicic acid as an adsorbent followed by gradient elution. Each fraction was rechromatographed to yield a total of 16 subfractions. Two compounds, carnosol and ursolic acid, were identified by infrared, mass and nuclear magnetic resonance spectrometry. Carnosol was shown to be one of the active antiox...
144 Citations Source Cite
Published on May 1, 1987in Journal of Ethnopharmacology 3.12
Armando Cáceres26
Estimated H-index: 26
(University of San Carlos),
Lidia M. Girón7
Estimated H-index: 7
,
Ana M. Martínez1
Estimated H-index: 1
Through ethnobotanical surveys in Guatemala, about 250 plants were identified for use in the treatment of urinary ailments. From 67 of these, aqueous extracts were prepared to investigate their oral diuretic activity in albino rats after a dose equivalent to 1 gkg of dried plant material. The trials demonstrated that in 33 cases urinary excretion was not significantly increased ( 189%). Control treatment increased urine output an average of 36% while 25 mgkg hydrochlorothiazide treatment increas...
125 Citations Source Cite
Published on Feb 1, 1991in Planta Medica 2.49
Tayfun Berkan3
Estimated H-index: 3
,
Levent Üstünes8
Estimated H-index: 8
+ 1 AuthorsAsli Özer6
Estimated H-index: 6
Erytraea centaurium is a plant which is used in the treatment of various inflammatory conditions in popular medicine. The extract exhibited antiinflammatory and antipyretic activity although no analgesic activity was observed.
41 Citations Source Cite
Published on Dec 1, 1991in Journal of Ethnopharmacology 3.12
Jamal Bellakhdar1
Estimated H-index: 1
,
Renée Claisse1
Estimated H-index: 1
+ 1 AuthorsChafique Younos17
Estimated H-index: 17
(Metz)
Abstract The traditional uses of plants for medicine were studied in Morocco. To this date, 231 medicinal plants belonging commonly to the Moroccan pharmacopoea have been identified and are presented in a table with the vernacular name in Arabic and/or Berber, the ecological distribution, the useful part and the medicinal use. The study of the main therapeutic indications of the medicinal plants gives a clear picture of the health problems which are treated by traditional medicine in Morocco.
203 Citations Source Cite
Published on Jul 1, 1994in Journal of Ethnopharmacology 3.12
A.A. Al-Hader2
Estimated H-index: 2
(Jordan University of Science and Technology),
Z.A. Hasan2
Estimated H-index: 2
(Jordan University of Science and Technology),
M. Aqel11
Estimated H-index: 11
(University of Jordan)
Abstract The effects of the volatile oil extracted from the leaves of Rosmarinus officinalis on glucose and insulin levels were investigated in normal rabbits, after the administration of an intraperitoneal glucose tolerance test (GTT). Also, the effects of the volatile oil on fasting plasma glucose levels, were studied in alloxan diabetic rabbits. In normal rabbits, the intramuscular (i.m.) administration of the volatile oil (25 mg/kg) produced 20% ( P P P P R. officinalis volatile oil increase...
54 Citations Source Cite
Cited By115
Published on Jan 1, 2012in Advances in food and nutrition research
Soňa Škrovánková3
Estimated H-index: 3
(Tomas Bata University in Zlín),
Ladislava Mišurcová10
Estimated H-index: 10
(Tomas Bata University in Zlín),
Ludmila Machů4
Estimated H-index: 4
(Tomas Bata University in Zlín)
Abstract Medicinal plants are traditionally used in folk medicine as natural healing remedies with therapeutic effects such as prevention of cardiovascular diseases, inflammation disorders, or reducing the risk of cancer. In addition, pharmacological industry utilizes medicinal plants due to the presence of active chemical substances as agents for drug synthesis. They are valuable also for food and cosmetic industry as additives, due to their preservative effects because of the presence of antio...
55 Citations Source Cite
Published on Oct 1, 2015in Trends in Food Science and Technology 6.61
Regiane Ribeiro-Santos7
Estimated H-index: 7
(Federal Fluminense University),
Denise Carvalho-Costa2
Estimated H-index: 2
(University of Porto)
+ 6 AuthorsAna Sanches-Silva20
Estimated H-index: 20
(University of Porto)
Abstract Background Rosemary ( Rosmarinus officinalis L.) is a widely consumed aromatic plant that belongs to the Lamiaceae family. Fresh and dried leaves are frequently used in traditional Mediterranean cuisine and in folk medicine. Scope and approach For this study, an extensive bibliographic review on rosemary was carried out, including its main uses, components (both nutrients and bioactive), biological activities, interactions with drugs and potential applications. Key findings and conclusi...
31 Citations Source Cite
Published on Jun 30, 2014in Journal of Advances in Chemistry
Manel Ben Ali4
Estimated H-index: 4
(University of Sfax),
Kais Mnafgui10
Estimated H-index: 10
(University of Sfax)
+ 2 AuthorsNoureddine Allouche14
Estimated H-index: 14
(University of Sfax)
Diabetes mellitus is a serious health problem worldwide that has adverse and long-lasting consequences for individuals, families, and communities. Hence, this study sought to investigate the inhibitory potential of rosemary extracts on key-enzymes related to diabetes such as α-amylase and pancreatic lipase activities, as well as to assess their antioxidant properties in vitro. The IC 50 values of Rosemary essential oil, ethyl acetate and methanolic extracts against α-amylase were 28.36, 34.11 an...
2 Citations Source Cite
Published on Dec 9, 2016in Critical Reviews in Food Science and Nutrition 6.20
Allyson M. Bower3
Estimated H-index: 3
(University of Illinois at Urbana–Champaign),
Susan Marquez1
Estimated H-index: 1
(University of Illinois at Urbana–Champaign),
Elvira Gonzalez de Mejia39
Estimated H-index: 39
(University of Illinois at Urbana–Champaign)
The Mediterranean diet is considered one of the healthiest diets in the world. This is often attributed to low saturated fat consumption, moderate wine consumption, and high vegetable consumption. However, herbs and spices associated with these diets may also play an important role in the quality of this diet. This review summarizes the most recent research regarding the anti-diabetic, anti-inflammatory, anti-hyperlipidemic and anti-hypertensive properties of this collection of culinary species....
14 Citations Source Cite
Published on Sep 1, 2013in Journal of Crop Protection
Elham Yazdani3
Estimated H-index: 3
,
Jalal Jalali Sendi13
Estimated H-index: 13
(University of Gilan),
Alireza Aliakbar8
Estimated H-index: 8
Mulberry pyralid, Glyphodes pyloalis Walker is an important pest on mulberry. The essential oil of Rosemary Rosemarinus officinalis L. (Lamiales: Lamiaceae) has been investigated on toxicity and physiological characteristics of this moth under controlled conditions. The major compounds of the oil were analyzed as 1, 8 Cineol (20.021%), Borneol (7.17%), Camphor (6.541%), Geraniol (6.281%), Camphene (5.623%), Linalool (4.993%) Alpha fenchyl acetate (4.222%) and Verbenone (4.147%). Lethal and suble...
6 Citations
Published on Apr 1, 2009in Sozial-und Praventivmedizin
M. Eddouks1
Estimated H-index: 1
,
A. Khalidi1
Estimated H-index: 1
,
N. A. Zeggwagh1
Estimated H-index: 1
L’hypertension arterielle represente un probleme majeur de sante publique. Selon l’Organisation mondiale de la sante (OMS), plus de 20 % de la population mondiale souffre des anomalies de la pression arterielle. Les etudes pharmacologiques ont supporte l’usage traditionnel de nombreuses plantes medicinales utilisees dans la pharmacopee marocaine pour le traitement de l’hypertension. Ce travail presente une synthese des etudes sur la phytotherapie de l’hypertension au Maroc.
1 Citations Source Cite
MartynyukLiliya1
Estimated H-index: 1
,
MartynyukLarysa1
Estimated H-index: 1
+ 1 AuthorsMartynyukOlena1
Estimated H-index: 1
Abstract Objectives: Diabetic nephropathy (DN) is a serious and common complication of diabetes mellitus leading to end-stage renal disease in up to 30% of diabetic patients. The first manifestation of DN in humans is microalbuminuria, which arises from the increased passage of albumin through the glomerular filtration barrier. Reactive oxygen species, inflammatory cytokines, and growth factors are key players in the context of damage to the glomerular filtration barrier. Interventions: In this ...
4 Citations Source Cite
Published on Dec 1, 2013in Sozial-und Praventivmedizin
Semi Anthelme Nene-Bi1
Estimated H-index: 1
(Université Félix Houphouët-Boigny),
Tianga Yaya Soro1
Estimated H-index: 1
(Université Félix Houphouët-Boigny)
+ 1 AuthorsFlavien Traore3
Estimated H-index: 3
(Université Félix Houphouët-Boigny)
Bridelia ferruginea est une plante de la pharmacopee traditionnelle africaine intervenant dans le traitement de plusieurs pathologies. Elle est utilisee comme purgatif et possede des proprietes diuretiques. L’objectif de la presente etude est d’evaluer l’effet sur la fonction renale d’un extrait aqueux de l’ecorce de tige de cette plante chez le rat mâle de souche Wistar. L’extrait aqueux de Bridelia ferruginea (SEA), 24 heures apres son administration au rat, provoque une augmentation de l’excr...
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Published on Dec 1, 2015in Clinical Phytoscience
Volodymir Medved1
Estimated H-index: 1
(Academy of Medical Sciences, United Kingdom)
Background Urinary tract infections (UTIs) are among the most commonly occurring bacterial infections, particularly in pregnant women. Canephron® N (Bionorica, Germany) is a phytotherapeutic medicinal product that has pleiotrophic effects on the urinary system, including diuretic, spasmolytic, anti-inflammatory, antimicrobial and nephroprotective effects. The purpose of this retrospective study was to assess the safety of Canephron® N when used in the first trimester of pregnancy for the treatme...
1 Citations Source Cite
Rachad Alnamer3
Estimated H-index: 3
,
Katim Alaoui7
Estimated H-index: 7
+ 2 AuthorsYahia Cherrah13
Estimated H-index: 13
Abstract Leaves of Rosmarinus officinalis and the flowers of Lavandula officinalis have been used as medicine for treatment of nervous disorders, in traditional Moroccan medicine. We evaluate the central nervous system psychotropic effects of the essential oil from the leaves of R. officinalis and the flowers of L. officinalis using a battery of comportamental psychopharmacology tests. The essential oil extracted by hydrodistillation were characterized by means of GC-MS. R. officinalis contained...
6 Citations Source Cite