Sessile serrated adenomas and classical adenomas: An epigenetic perspective on premalignant neoplastic lesions of the gastrointestinal tract

The diagnosis of sessile serrated adenomas (SSAs) is challenging, and there is a great deal of interobserver variability amongst pathologists in differentiating SSAs from hyperplastic polyps (HPPs). The aim of this study was ( i ) to assess the utility of epigenetic changes such as DNA methylation in differentiating SSAs from HPPs and ( ii ) to identify common methylation based molecular markers potentially useful for early detection of...