UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

Nature64.80
Volume: 454, Issue: 7206, Pages: 846 - 851
Published: Aug 14, 2008
Abstract
The gut-derived hormone ghrelin exerts its effect on the brain by regulating neuronal activity. Ghrelin-induced feeding behaviour is controlled by arcuate nucleus neurons that co-express neuropeptide Y and agouti-related protein (NPY/AgRP neurons). However, the intracellular mechanisms triggered by ghrelin to alter NPY/AgRP neuronal activity are poorly understood. Here we show that ghrelin initiates robust changes in hypothalamic mitochondrial...
Paper Details
Title
UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals
Published Date
Aug 14, 2008
Journal
Volume
454
Issue
7206
Pages
846 - 851
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