Phosphorylation of PCNA by EGFR inhibits mismatch repair and promotes misincorporation during DNA synthesis

Significance DNA replication accuracy is critical for genetic stability and is ensured by high-fidelity replicative DNA polymerases and the mismatch repair (MMR) system, both of which are regulated by the proliferating cell nuclear antigen (PCNA). Dysfunction of either system leads to genome instability and cancer development. Interestingly, many types of cancers have no obvious defects in either system, but they display increased mutation...