FATP4 contributes as an enzyme to the basal and insulin-mediated fatty acid uptake of C₂C₁₂muscle cells

The function of membrane proteins in long-chain fatty acid transport is controversial. The acyl-CoA synthetase fatty acid transport protein-4 (FATP4) has been suggested to facilitate fatty acid uptake indirectly by its enzymatic activity, or directly by transport across the plasma membrane. Here, we investigated the function of FATP4 in basal and insulin mediated fatty acid uptake in C 2 C 12 muscle cells, a model system relevant for fatty acid...