An Optimum Principle Predicts the Distribution of Axon Diameters in Normal White Matter

Many important functional properties affecting nerve conduction are influenced by axon diameter. It is also known that the axon diameter distribution (ADD) in normal nerve fascicles is heterogeneous and skewed. A recent attempt to model and explain the parametric form of these distributions was based on biomechanical principles. Here we explore a neurophysiologically-based hypothesis that the observed ADD can be obtained by optimizing the...