Laparoscopic sleeve gastrectomy leads to rapid improvement of glucose tolerance and insulin secretion with enhanced glucagon-like peptide (GLP-1) secretion

To examine the effect of laparoscopic sleeve gastrectomy (LSG) on glucose metabolism. LSG was performed in two patients with diabetes and one with impaired glucose tolerance. An oral glucose tolerance test (OGTT) was performed preoperatively and 3 months postoperatively. Plasma glucose, insulin, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) levels were measured during the OGTT. Fasting ghrelin levels were...