Exendin-4 is effective against metabolic disorders induced by intrauterine and postnatal overnutrition in rodents
Abstract
Aims/hypothesis
Maternal obesity leads to increased adiposity, hyperlipidaemia and glucose intolerance in offspring. The analogue of glucagon-like peptide-1, exendin-4 (Ex-4), has been shown to induce weight loss in both adolescence and adulthood. We hypothesised that, in rats, daily injection of Ex-4 would reduce body fat and improve metabolic disorders in offspring from obese dams, especially those consuming a high-fat diet...
Paper Details
Title
Exendin-4 is effective against metabolic disorders induced by intrauterine and postnatal overnutrition in rodents
Published Date
Dec 14, 2013
Journal
Volume
57
Issue
3
Pages
614 - 622
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Notes
History